Informing people with Parkinson’s disease of their gene variant status: PD GENEration, a North American observational and registry study
Objective: To describe genetic testing results of major genes for Parkinson’s disease (PD) in a North American cohort as part of PD GENEration Background: Although…local field potential differences in stn subregion during performance of a conflict task in humans with parkinson’s disease
Objective: Examine dorsal and ventral STN subregion's roles in motor conflict with intraoperative recordings during the implantation of a DBS device in Parkinson’s disease (PD)…Physical exercise as a promising option for treating fatigue in Parkinson’s disease? Results of a systematic review and meta-analysis of non-pharmacological interventions
Objective: To give an update on randomized controlled trials (RCT) including non-pharmacological intervention approaches that examine effects on fatigue in people with Parkinson’s disease (PD).…Timed-up-and-go tests under dual-task conditions: Influence of different tasks on gait parameters in Parkinsonian patients
Objective: To analyse the effect of dual tasking on the Parkinson gait. Background: Parkinson's disease has a strong impact on gait and posture, leading to…AAV5-miHTT gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington’s disease minipigs up to 5 years
Objective: Our objective is to assess long-term safety of and durability of an adeno-associated viral vector serotype 5 encoding an engineered miRNA (AAV5-miHTT) targeting human…An IMU- based Objective Quantification Method for Bradykinesia Evaluation in Parkinson’s disease
Objective: Proposing an inertial measurement unit (IMU)-based objective quantification method for bradykinesia evaluation in Parkinson’s disease (PD) using MDS UPDRS III. Background: MDS-UPDRS III rating…Efficacy and safety of Mexiletine versus Placebo in patients with myotonia: A Systematic Review and Meta-analysis
Objective: We conducted this study to be the first systematic review and meta-analysis to investigate the efficacy and safety of mexiletine in the treatment of patients…Connectomic DBS informed multifocal transcranial direct current stimulation (tDCS) in Parkinson’s Disease: a crossover double blinded study
Objective: To determine if non-invasive neuromodulation of a network previously identified through invasive neuromodulation could improve motor symptoms in Parkinson's disease (PD). Background: A recent…Automated parcellation of the cerebellum in patients with newly diagnosed Parkinson’s disease
Objective: Quantitatively evaluate the gross morphology of individual cerebellar lobules, determine whether cerebellar anatomical changes occur early in the disease and whether changes were related…Olfactory discrimination ability is associated with subjective lack of social support in female Parkinson’s patients
Objective: We aimed to explore the relationship between olfactory discrimination ability and subjective social support in a sample of patients with Parkinson’s Disease. We hypothesized…
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