AAV5-miHTT gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington’s disease minipigs up to 5 years
Objective: Our objective is to assess long-term safety of and durability of an adeno-associated viral vector serotype 5 encoding an engineered miRNA (AAV5-miHTT) targeting human…Digital gait and turning impairments (quality but not quantity) during daily life are more severe in retrospective fallers compared to non-fallers with Parkinson’s disease
Objective: To investigate which specific digital gait and turning measures, obtained with body-worn sensors, best differentiate fallers from non-fallers with PD during daily life. Background:…Informing people with Parkinson’s disease of their gene variant status: PD GENEration, a North American observational and registry study
Objective: To describe genetic testing results of major genes for Parkinson’s disease (PD) in a North American cohort as part of PD GENEration Background: Although…“Speaking aids in neurodegenerative ataxia: how to deal with own disability”
Objective: To highlight the role of self-initiated coping strategies in symptoms management of patients with neurodegenerative ataxia. Background: Ataxia is a neurological condition that manifests…Long-term outcomes of deep brain stimulation for VPS16-related dystonia: A multi-center international study
Objective: To evaluate long-term effects of DBS in an international cohort of people with VPS16-related dystonia. Background: Variants in VPS16 gene have recently been related…Vertigo: Sway pattern indicating a functional movement disorder
Objective: To estimate the value of static posturography (PUG) to detect functional postural instability in patients with acute vertigo syndromes in an emergency department Background:…Case report- Cavernoma involving substantia nigra and nigrostriatal pathway as a rare cause of secondary parkinsonism with a 3 year follow up
Objective: To describe a case report of a rare cause of Parkinsonism Background: Vascular malformations such as cerebral cavernomas are known to predispose to haemorrhagic…Age at Onset and Therapeutic Efficacy of Primidone in Essential Tremor Patients
Objective: To study the therapeutic response of primidone in different age groups of Essential Tremor (ET) patients, based on age at onset. Background: Essential Tremor…Challenges in patient-physician communication during limited time appointments in Parkinson’s disease
Objective: Our aim is to analyze challenges in patient-physician communication during limited time appointments in Parkinson’s disease (PD). Background: Due to limited number of movement…Motor complications in Parkinson’s disease
Objective: To determine the presence, severity, functional impact and predisposing factors of motor complications. Background: Motor complications are well recognized in Parkinson’s disease (PD), but…
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