Clove mediated Rescue in Parkinson’s Disease involves modulation of p53 and Sestrin2 in SHSY5Y cell line model
Objective: The study analyzed the neuroprotective effect of ethanolic extract of clove against Parkinson’s disease (PD) type toxicity in SHSY5Y cell line model and interrogation…Phosphorylated α-synuclein at serine residue 129 decreased in Parkinson’s disease patients taking 250mg of daily niacin for six months
Objective: The main objective was to determine if α-synuclein could be modulated by niacin supplementation, contributing to improved Parkinson’s disease (PD) symptoms. Background: Niacin supplementation…Challenges in Outcome Measure Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease
Objective: The Edmond J Safra Accelerating Clinical Trials in Parkinson Disease (PD) initiative (EJS ACT-PD) aims to accelerate the identification of disease modifying treatment for…Facial to diaphragmatic spasms: A tale of misfortune
Objective: To describe a case of recurrent intractable hiccups (diaphragmatic spasms) developed following microvascular decompression for right hemifacial spasms. Background: A 59-year-old male was seen…Predictors of short-term anxiety outcome after subthalamic stimulation in Parkinson’s Disease
Objective: To identify clinical predictors of the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s Disease (PD). Background: STN-DBS is a…Frequency of non-motor symptoms in GBA-PD may differ in carriers of mild vs. severe pathogenic variants
Objective: Parkinson's disease (PD) patients with pathogenic variants in the GBA (glucocerebrosidase) gene (GBA-PD) were reported to exhibit a younger age at onset, faster progression…Asymmetry of Motor and Non-motor Signs in Parkinson’s Disease: An Exploratory Clinical Case-control Study
Objective: To identify, quantify and correlate asymmetry between motor and non-motor signs in early Parkinson’s disease (PD). Background: Asymmetry of motor signs in PD reflects…Deleterious GRN mutations: a new player in the etiology of Lewy body dementia
Objective: In this study we investigated the association of GRN damaging mutations in the etiology of Lewy body dementia. Background: Lewy body dementia (LBD) is…PONTINE AND EXTRAPONTINE MYELINOLYSIS PRESENTING AS ACUTE PARKINSONISM
Objective: To report a patient with acute onset parkinsonism due to extrapontine myelinosis. Background: Osmotic demyelinating diseases of the central nervous system appear to be…Dried blood and plasma spots for the measurement of neurofilament light chain and inflammatory cytokines in patients with REM sleep behaviour disorder
Objective: The objective of this study was to investigate the relationship between plasma and dried blood/ plasma spot measurements of inflammatory markers (IFN-ɣ, IL-1β, IL-6,…
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