Drug-induced Parkinsonism and nonmotor symptoms: a case of gustatory rhinorrhea
Objective: We aim to emphasize the relevance of contemplating nonmotor symptoms as possible features of drug-induced parkinsonism, and the utmost importance of further investigation in…Childhood-onset writer’s cramp evolving to generalised dystonia –a new mutation in KMT2B gene
Objective: To present a case of childhood-onset dystonia with a new mutation in KMT2B gene. Background: KMT2B-related dystonia (DYT-KMT2B) is an increasingly recognized cause of…Practice and outcome variation across Parkinson’s Foundation Centers of Excellence
Objective: To identify center-level variations in Parkinson’s disease (PD) treatment practices and outcomes, and the relationship between treatment and outcomes to inform best practices Background:…Subthalamic Nucleus Deep Brain Stimulation in GBA-associated Parkinson Disease: Cognitive and motor follow-up of two clinical cases
Objective: To report the long-term motor and cognitive outcome of two patients with GBA-associated Parkinson’s disease (PD) who underwent STN-DBS surgery. Background: Recent studies suggest…Acute-onset parkinsonism secondary to bilateral extrapontine myelinolysis of the basal ganglia: case report
Objective: Although rapid osmolar correction, mainly in the setting of hyponatremia is the main risk factor of osmotic demyelination syndrome, the pathogenesis of the syndrome…Identification of xylopropamine as a potential dopamine D2 receptor agonist through computational drug discovery pipeline
Objective: This study aims to identify novel dopamine D2 receptor agonists through the computational drug discovery pipeline. Background: Parkinson's disease (PD) is a neurodegenerative disorder…Clinical features and phenoconversion risk in women with isolated REM sleep behavior disorder
Objective: To determine features predictive of differential phenoconversion rates in isolated REM sleep Behavior Disorder (iRBD) to a defined neurodegenerative disease (NDD). Background: iRBD is…Linking volume of tissue activated to neural oscillations in deep brain stimulation
Objective: Exploring the effect of deep brain stimulation (DBS) settings on neural oscillations in Parkinson’s disease (PD) patients with subthalamic nucleus (STN) DBS and their…Evaluation of a novel Phosphodiesterase 5 inhibitor as a potential therapeutic agent in P301S transgenic mouse model of tauopathy.
Objective: In the current study, we evaluated a newly developed compound with a 1,3,5-trisubstituted pyrazoline scaffold with an improved PDE5 inhibitory potency as a potential…Acute laryngeal stridor in the emergency department: pandemic or additional sign?
Objective: To highlight the importance of early recognition of the broader spectrum of clinical features of MSA and specially the sleep-related breathing disorders, as stridor.…
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