Obsessive-Compulsive symptoms in Parkinson’s Disease: beyond the Impulse Control Disorders
Objective: To characterize the obsessive-compulsive symptoms (OCS) and Impulse Control Disorders (ICD) in patients with Parkinson’s Disease (PD), as well as explore the correlation between…Evaluation of a novel Phosphodiesterase 5 inhibitor as a potential therapeutic agent in P301S transgenic mouse model of tauopathy.
Objective: In the current study, we evaluated a newly developed compound with a 1,3,5-trisubstituted pyrazoline scaffold with an improved PDE5 inhibitory potency as a potential…Progressive myoclonic epilepsy ataxia syndrome associated with NUS1 gene mutation
Objective: To describe a rare case of NUS1 gene mutation related progressive epilepsy myoclonus ataxia syndrome. Background: Pathogenic variants of NUS1 gene have been associated…Cortical Control of Gait and Balance During Single and Dual Tasks in Huntington’s Disease: an fNIRS study
Objective: To examine the cortical control of gait and balance in HD under single-task (ST) and dual-task (DT) conditions compared to healthy controls using portable…A randomized, phase 2a, double-blind, placebo-controlled clinical trial with NE3107 adjunctive to carbidopa/levodopa in patients with Parkinson’s disease
Objective: To evaluate the motor effects of NE3107 treatment in patients with levodopa-treated Parkinson’s disease (PD) experiencing motor fluctuations. Background: NE3107 is an oral, blood-brain…Differential effect of MAPT haplotype on survival in CBD and PSP-SCB phenotype
Objective: Evaluate the association of MAPT haplotype with the risk of PSP-CBS and CBD severity of tau pathology by studying the survival rate of both…A 20-Year Follow-Up Case Report with Three DaT-SPECT Scans in Parkinson’s Disease Diagnosis
Objective: To describe a patient who underwent multiple DAT-SPECT scans over a 20-year clinical follow-up period in three distinct clinical settings: a normal scan excluding…The effect of subthalamic therapeutic deep brain stimulation on pallidal and cortical activity in Parkinson’s disease
Objective: To evaluate the effect of subthalamic (STN) deep brain stimulation (DBS) on the globus pallidus (GP) and motor cortex Background: Progressive neuronal loss in…Investigate the association of MAPT haplotype and neuroanatomical structure and its influence on the risk of Parkinson’s disease
Objective: To investigate if the vulnerability of Parkinson’s Disease (PD) can be reflected in the neuroanatomical structure in different MAPT haplotype carriers. Background: It has…Development of a Vibro-Tactile Stimulation wristband for targeted therapy of Focal Task Specific Dystonias
Objective: To design and develop a wristband that provides vibro-tactile stimulation as a sensory geste/trick for patients with FTSDs. The device will offer different frequencies…
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