Multimodal mechanistic disease stratification in sporadic Parkinson’s disease
Objective: To mechanistically stratify Parkinson’s disease (PD), applying a combination of putaminal 31Phosphorus magnetic resonance spectroscopy (31P-MRS) with detailed assessment of mitochondrial and lysosomal function…Comparison between clinical and kinematic assessment of bradykinesia
Objective: To compare the clinical and kinematic assessment of bradykinesia (movement slowness). Background: Bradykinesia may be present not only in Parkinson’s disease (PD), but also…Diagnosis of Niemann-Pick type C disease: adult onset form
Objective: We present a case of Niemann-Pick disease type C (NP-C) with adult onset. We review the clinical presentation, diagnosis and treatment of this rare…Amelioration of Levodopa-induced Dyskinesias using Genetic Silencing of Striatal CaV1.3 in Parkinsonian Rats: Impact of Sex and Advancing Age
Objective: To advance understanding of striatal CaV1.3 (cacna1d) channel silencing as a therapeutic approach to reduce levodopa-induced dyskinesias (LID), a side effect of long-term escalating…Nigral microvasculature imaging in Parkinson’s disease
Objective: The goal of this work is to image the microvasculature of the midbrain, in particular the substantia nigra in Parkinson’s disease (PD) patients using…BRAIN REGIONAL HYPOMETABOLISM PROGRESSION IN iRBD: THE COGNITIVE ROLE OF OCCIPITAL HYPOMETABOLISM
Objective: To understand functional brain changes over time in isolated REM sleep behaviour disorder (iRBD), we investigated the progression of regional hypometabolism in iRBD patients…Correlation of Voice parameters and Dysphagia Severity in Multiple System Atrophy
Objective: To investigate the correlation between speech parameters and dysphagia severity in patients with MSA. Background: Dysphagia is an early and underestimated symptom in MSA…Quality of Life and Motor Outcomes for Parkinson’s Disease Patients 12 Months After Deep Brain Stimulation in China
Objective: Demonstrate improvement in Parkinson’s disease (PD)-related quality of life (QoL) for Deep Brain Stimulation (DBS) patients in a prospective, multicenter study conducted in China.…Longitudinal Program to Prevent PD (LoPP-PD): Multimodal Risk Stratification Informs Personalized Intervention
Objective: Longitudinal evaluation of personalized intervention strategies informed by detailed clinical and laboratory biomarker analysis to reduce relative risk of Parkinson’s disease in first degree…Electrophysiology and clinical description of Tremor in Spinocerebellar Ataxia 12 (SCA12)
Objective: To describe the clinical and electrophysiological characteristics of tremor in SCA12. Background: There is scarcity of literature on tremor of SCA12 patients which is…
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