Inclusion of PSP-Parkinsonism (PSP-P) phenotype in clinical trials – power calculation
Objective: PSP-P is the second most common PSP phenotype. To facilitate its inclusion in future clinical trials, we used longitudinal data from the TAUROS study…Assessing Feasibility of Using Phone Video Data in Diagnosing Parkinsonism
Objective: This project aims to address potential gaps in rural healthcare by assessing the feasibility of using mobile phone data to identify features of parkinsonism…Focused Ultrasound Therapy Treatment for Parkinson’s Disease
Objective: Parkinson’s Disease is a neurodegenerative disease that mainly affects the substantia nigra and nigrostriatal pathway and leads to rigidity, loss of muscle tone, tremors,…The Challenges of Very Late-Onset Parkinson’s Disease: Perspectives from Patients, Primary Caregivers and Attending Physicians.
Objective: The purpose of this study is to investigate the difficulties faced by very late-onset patients with Parkinson’s disease (PD), caregivers and attending physicians, and…Association Between Clinical Progression in Multiple System Atrophy and Brain Volume Changes Evaluated via Deep Learning Segmentation
Objective: Assess brain volume changes in patients with multiple system atrophy (MSA) over one year. Background: Identifying disease progression biomarkers is crucial for advancing MSA…Safety and Efficacy of the Anti-alpha Synuclein Monoclonal Antibody Lu AF82422 for the Treatment of Patients with MSA: Results from the Phase 2 AMULET Trial
Objective: Assess the efficacy and safety of monthly IV infusions with the anti-alpha synuclein [a-syn] monoclonal antibody Lu AF82422 for the treatment of patients with…Exploring Vestibulopathy in PD: Distinguishing PD from Age-related Presbyvestibulopathy via Dynamic Gait and Balance Assessment
Objective: To investigate the influence of age-associated vestibulopathy (presbyvestibulopathy, PVP) on dynamic gait and balance in Parkinson's disease (PD) patients and elderly controls. We hypothesized…Early Dementia with Lewy Bodies and Parkinson’s Disease with RBD: two faces of the same coin?
Objective: To describe clinical and imaging differences in de novo PD with and without REM sleep Behaviour Disorder (dnPDRBD – de novo PD) and de…α-Synuclein Pathology Across Movement Disorders and Neurodegenerative Diseases by Seed Amplification Assay
Objective: To assess the frequency of pathological α-synuclein (αSyn) in various movement disorders and neurodegenerative diseases from a specialized movement disorder clinic by αSyn seed…A Phase 2 Study of ATH434 a Novel Inhibitor of α-Synuclein Aggregation for the Treatment of Multiple System Atrophy
Objective: Describe baseline fluid and neuroimaging biomarker data of an early MSA study population Background: MSA is a rapidly progressive neurodegenerative disorder characterized by aggregated…
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