Objective: To assess objective measurements by Personal KinetiGraph (PKG) in Parkinson’s disease (PD) patients and compare them to self-reported symptoms.  

Background: Personal Kinetigraph (PKG) is a medical device which provides objective measurements of PD symptoms. The commonly used measures include bradykinesia scores (BKS), dyskinesia scores (DKS) and fluctuation and dyskinesia scores (FDS). A BKS >26 and DKS >9 are associated with poorly controlled bradykinesia and dyskinesia, respectively. The FDS summarizes the interquartile range of bradykinesia and dyskinesia across all the days of recording and a score >12.8 is associated with uncontrolled fluctuations. There is limited literature on the utility of PKG in movement disorder clinics; therefore, we report our experience with PKG.

Methods: Patients with Parkinson’s disease evaluated in clinic were given PKG to be worn for 6 days. The data obtained from PKG was analyzed and compared with self-reported duration of OFF time and dyskinesia.  

Results: A total of 145 patients with PD were included in the analysis. The mean age of patients (M=95, F =50) was 65.6 years (SD 9.64). A BKS >26 was recorded in 65 patients, of these 64.6% (n=42) reported 0.5-4 hrs of OFF time, 17 % (n=11) reported >4 hrs of OFF time and 18.4% (n=12) reported no OFF time. A BKS <26 was recorded in 80 patients, of these 68.7% (n=55) reported 0.5-4 hrs of OFF time, 18.7% (n=15) reported >4 hrs of OFF time and 12.5% (n=10) reported no OFF time. A DKS >9 was recorded in 18 patients, of these 50% (n=9) reported 0.5-4 hrs of dyskinesia, 33.3% (n=6)reported >4 hrs of dyskinesia and 16.6% (n=3) reported no dyskinesia. A DKS <9 was recorded in 127 patients, in this group 55.1% (n=70) reported 0.5-4 hrs of dyskinesia, 7.8% (n=10) reported >4 hrs of dyskinesia and 37% (n=47) reported no dyskinesia. A FDS >12.8 was recorded in 22 patients, of these 45.4% (n=10) reported 0.5-4 hrs of both dyskinesia and bradykinesia and only one patient reported no dyskinesia or bradykinesia.

Conclusions: PKG may assist in assessing motor symptoms in PD; however further studies are needed to support the utility of PKG in movement disorder clinics.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/personal-kinetigraph-pkg-for-parkinsons-disease-experience-at-a-tertiary-care-center/