Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The aim of this study is to validate practical and objective measures to assess changes in rigidity and tremor due to micro-lesion effects and test stimulation during deep brain stimulation (DBS) surgery.
Background: Several factors contribute to accuracy and success of electrode placement during DBS surgery for Parkinson’s disease. Intra-operative test stimulations and subsequent evaluation of beneficial as well as potential adverse effects are the final and perhaps most important step in placement accuracy. However, these subjective clinical evaluations rely on clinical experience and expertise and are accompanied by both inter- and intra-rater variability. Objective quantification of baseline symptomatology, as well as subtle symptom changes, can standardise assessment, minimize variability and further improve surgical accuracy and more importantly clinical outcomes.
Methods: Appropriate tremor or rigidity measurements (accelerometer and passive resistance) were taken at three time points with and without dual task, 1) before insertion of the electrode 2) directly following insertion prior to test stimulation and 3) during test stimulation at target level.
Results: Data has been collected from one patient so far and preliminary analysis shows an immediate and significant reduction in rest tremor upon electrode placement and subsequent test stimulation. Data collection is currently ongoing and our aim is to finalize data collection for tremor and rigidity changes from at least 10 consented patients by early February. This will allow a complete and detailed report of analysis and results at time of presentation.
Conclusions: The preliminary data looks promising and the practicality of objective tremor measures is unambiguous. Together with newly collected data report will allow for clear conclusions regarding the validity, applicability and standardization of tremor and rigidity measures during DBS surgery.
To cite this abstract in AMA style:
P. Poortvliet, A. Fytagoridis, T. Coyne, P. Silburn. Quantification of tremor and rigidity during deep brain stimulation surgery for Parkison’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/quantification-of-tremor-and-rigidity-during-deep-brain-stimulation-surgery-for-parkisons-disease/. Accessed May 18, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/quantification-of-tremor-and-rigidity-during-deep-brain-stimulation-surgery-for-parkisons-disease/