Objective: The present study has an attempt to understand cadmium induced alteration in dopamine and associated signaling that causes the motor alterations in rats and at the time to assess whether quercetin have protective potential in combating such changes.

Background: Release of dopamine at synapse and related alteration in presynaptic and postsynaptic signaling is the key contributor to regulation of motor functions at synapse. Alteration in the level of dopamine or its metabolites leads to disturb the dopamine neurotransmission leading to development to various neurological and psyological disturbances. Cadmium (Cd) is a perpetual toxin with high occurrence in nature and importantly considered as potential risk factor in the development Parkinson’s disease but the mechanism behind the development of disease is still a question need to solve.

Method: Using rat model, four experimental groups are classified. Rats exposed to cadmium (5 mg/kg bw, p.o.) or Quercetin (25mg/kg bw, p.o.) or simultaneous exposure to cadmium & quercetin for 28 days

Results: Studies carried out exhibits high levels of cadmium in various brain regions as frontal cortex, hippocampus and corpus striatum on cadmium exposure in rats as compared to controls. Further, cadmium treatment in rats decreases the dopamine levels at synapse. The Decrease level of DOPAC and HVA has also been found as of controls. The decrease expression of TH  has also been observed suggesting the auto feedback regulation through dopamine in such rats. The spontaneous locomotor activities and motor coordination was observed in rat exposed to cadmium. While simultaneous exposure with quercetin in cadmium exposed rats found to protect such changes as compared to cadmium exposed cells and in rats.

Conclusion: The results on the present study exhibits cadmium induced motor  dysfunction are regulated by dopamine and their metabolites levels at synapse and the protective potential of quercetin in modulating the such changes that may pave the way for its potential therapeutic intervention in various neurological disease conditions.

References: Gupta R, Shukla R.K., Pandey A., Sharma T., Dhuriya Y., Srivastava P., Singh MP., Siddiqi MI., Pant A. B., and Khanna V.K,. Involvement of PKA/DARPP32/PP1a and ß- arrestin/Akt/Gsk-3ß signaling in Cadmium Induced DA-D2 Receptor Mediated Motor dysfunctions: Protective Role of Quercetin. Sci Rep. 2018 Feb 6;8(1):2528

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MDS Abstracts - https://www.mdsabstracts.org/abstract/quercetin-regulates-cadmium-induced-motor-dysfunction-in-depletion-of-dopamine-and-its-metabolites-at-synapse/