Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate (1) the domains of cognitive impairment in patients with Parkinson’s disease (PD) and rapid eye movement sleep behavior disorder (RBD). (2) To explore risk factors for PD-mild cognitive impairment (PD-MCI) and relationship between RBD severity and impairment in different cognitive domains in PD.
Background: RBD may be a risk factor for cognitive impairment in patients with PD. However, little is known regarding the relation between the severity of RBD and the different domains of cognitive impairment.
Methods: The participants were grouped as follows: PD without RBD (PD-RBD; n = 42), PD with RBD (PD + RBD; n = 32), idiopathic RBD (iRBD; n = 15), and healthy controls ([HCs]; n = 36). Demographics, clinical characteristics,neuropsychological assessment and RBD Questionnaire-Hong Kong (RBDQ-HK) and the RBD Screening Questionnaire (RBDSQ) was obtained. 35 PD and all iRBD patients completed an overnight video-polysomnography. Then we further examined associations between the severity of RBD symptoms and cognitive levels via correlation analysis.
Results: Compared to PD-RBD subjects, PD+RBD patients were more likely to have olfactory dysfunction and their Epworth Sleepiness Scale scores were higher (P<0.05). During neuropsychological testing, PD+RBD patients performed worse than PD-RBD patients, including delayed memory function, especially. The MCI rates were 33.3%, 62.5%, 33.3%, and 8.3% for PD-RBD, PD+RBD, iRBD, and HC groups, respectively. RBD was an important factor for explaining the PD-MCI variance (odds ratio=5.204, P=0.018). During correlation analysis, higher RBD Screening Questionnaire and RBD Questionnaire-Hong Kong (RBD-HK) scores were significantly associated with poorer performance on the Trail Making Test-B (errors) and Auditory Verbal Learning Test (delayed recall), and higher RBD-HK scores were also associated with Rey-Osterrieth complex figure (copy) results
|Items||RBDSQ score||RBD-HK score|
|Attention and working memory|
|Digit span forward||-0.001||0.992||0.015||0.903|
|Digit span backward||-0.048||0.694||-0.052||0.671|
|SVFT, former 15 s||0.001||0.991||-0.050||0.684|
|SVFT, latter 45 s||0.022||0.859||-0.029||0.814|
|AVLT, immediate recall||-0.164||0.176||-0.119||0.328|
|AVLT, delayed recall||-0.313||0.008||-0.246||0.040|
|Rey-O figure, recall||-0.131||0.278||-0.171||0.156|
|Rey-O figure, copy||-0.160||0.185||-0.290||0.015|
|Clock Drawing Test||0.033||0.789||0.045||0.710|
|Items||Tonic density||Phasic density|
|Attention and working memory|
|Digit span forward||-0.009||0.967||0.010||0.963|
|Digit span backward||0.026||0.905||-0.020||0.927|
|SVFT, former 15 s||0.119||0.580||-0.052||0.809|
|SVFT, latter 45 s||-0.240||0.258||-0.256||0.227|
|AVLT, immediate recall||-0.091||0.671||-0.368||0.077|
|AVLT, delayed recall||-0.229||0.282||-0.336||0.109|
|Rey-O figure, recall||-0.462||0.023||0.329||0.117|
|Rey-O figure, copy||-0.244||0.251||-0.143||0.504|
|Clock Drawing Test||-0.193||0.367||-0.011||0.959|
Conclusions: PD+RBD patients have more olfactory dysfunction and worse daytime somnolence. RBD is an important risk factor for MCI, including delayed memory. Deficits in attention, executive function, verbal delayed memory, and visuospatial function were consistently associated with more severe RBD symptoms.
To cite this abstract in AMA style:J.R. Zhang, J. Chen, Z.J. Yang, H.J. Zhang, Y.T. Fu, Y. Shen, P.C. He, C.J. Mao, C.F. Liu. Rapid eye movement sleep behavior disorder symptoms correlate with domains of cognitive impairment in Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/rapid-eye-movement-sleep-behavior-disorder-symptoms-correlate-with-domains-of-cognitive-impairment-in-parkinsons-disease/. Accessed September 27, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/rapid-eye-movement-sleep-behavior-disorder-symptoms-correlate-with-domains-of-cognitive-impairment-in-parkinsons-disease/