Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To study the level of vitamin D in the serum of Parkinson’s disease patients in the involvement of disease risk.
Background: The Parkinson’s disease is a major cause of disability in the elderly. Its risk factors are relatively unknown. Recently, chronically inadequate vitamin D intake was proposed to play a significant role in the pathogenesis of Parkinson’s disease. According to the suggested biological mechanism, the Parkinson’s disease may be caused by a continuously inadequate vitamin D status leading to a chronic loss of dopaminergic neurons in the brain.Vitamin D deficiency is of particular interest because it is easily, safely, and inexpensively corrected with adequate supplementation.
Methods: The study was based on Bukhara region’s population suffering with PD, which was conducted in 2017-2018. Serum vitamin D was determined from blood of patients and control group.Plasma total 25(OH)D level was measured by a microplate enzyme immunoassay in PD patients (N=72) and controls (N=39). Serum 25(OH)D is the barometer for vitamin D status. Interpretation was as follow that 25(OH)D of < 20 ng/ml is considered to be vitamin D deficiency whereas a 25(OH)D of 21-29 ng/ml is considered to be insufficient. Statistical analysis was performed using GraphPad Prism 7 software for Mac.
Results: Gender and age at sampling of PD cases and control had no significance. Both vitamin D deficiency (total 25(OH)D<20ng/mL) and vitamin D insufficiency (total 25(OH)D<30ng/mL) are significantly associated with PD (P<0.05). Individuals with PD were three and half times as likely to be vitamin D deficient as controls ( OR: 2.3, 95% CI, 0.88–6.14) and also vitamin D insufficient patients have increased PD risk (OR:1.6, 95% CI, 0.72–3.53).We examined the relationship between symptom duration and vitamin D levels. Our data showed that total 25(OH)D concentrations were not correlated with symptom duration ( P=0.3).
Conclusions: The results are consistent with the suggestion that low serum vitamin D level predicts an elevated risk of Parkinson’s disease incidence.Because of the small number of cases and the possibility of residual confounding, large cohort studies are needed.
To cite this abstract in AMA style:M. Sanoeva, N. Mansurova. Relationship of Vitamin D deficiency with Parkinson’s disease risk [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/relationship-of-vitamin-d-deficiency-with-parkinsons-disease-risk/. Accessed November 29, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-of-vitamin-d-deficiency-with-parkinsons-disease-risk/