Objective: The goal of this study was to identify the subset of Sniffin Sticks Test odorants that could be used to differentiate patients with Parkinson’s disease

Background: Olfactory dysfunction is a common nonmotor symptom of Parkinson’s disease (PD) with odor identification being the most affected domain. Patients with essential tremor (ET), however, demonstrate normal values in specialized olfactory testing batteries.

Methods: We studied 157 patients with PD, 60 patients with ET and 136 controls matched for sex and age. All patients’ performance in odor identification test (subtest for Sniffin Sticks Test) was assessed.

Results: Patients of all groups were characterized by significant differences in odor identification test total score (р<0,001). Significant differences were found in identification of cinnamon, banana and liquorice odorants (p<0,05). Patients with PD and ET could be differentiated from control group by inability to identify apple odorant.

Conclusions: Our study has shown that a certain selection of odorants (cinnamon, lemon, liquorice, garlic, pineapple, rose, anise and fish) in Sniffin Sticks Test can be used to differentiate PD from healthy controls and patients with ET regardless of total score (TDI), which can help in optimizing preclinical olfactory screening.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/selection-of-odorants-for-diagnosis-of-parkinsons-disease/