Objective: This article made an elaboration of the correlation between serum vitamin D and cognitive function of PD.

Background: Recent years, studies have suggested that serum vitamin D plays an important role in the occurrence and development of Parkinson’s disease (PD).It plays a complex role mainly by binding with vitamin D receptor (VDR). Numerous studies have shown that vitamin D affects the non-motor symptoms of PD. Cognitive impairment, as one of the non-motor symptoms of PD, seriously affects the quality of life of PD patients. Based on current researches, the level of serum vitamin D is associated with cognitive function of PD.

Methods: 54 cases of PD patients and 51 healthy individuals were selected in this study.The level of serum 25 (OH) D in the morning fasting blood of the two groups were measured.According to H&Y stage, patients in the case group were divided into early stage PD group includes 39 patients at 1-2.5 stages and the late group includes 15 patients at 3-5 stages.Cognitive function was evaluated by using MMSE and MoCA.According to the diagnostic criteria of Parkinson’s disease with Dementia (PDD). PD patients were divided into PDD group (18 cases) and non-PDD group (36 cases). This study uses SPSS 17.0 to deal with the data collected.

Results: 1.The difference of serum vitamin D level and MoCA score between the two groups were statistically significant (P<0.05).2.The serum vitamin D level in PDD group was lower than that in non-PDD group (P<0.05).3.For PDD patients:the serum vitamin D level and MoCA score in PDD early group were higher than that in PDD late group(P<0.05).4.For non-PDD patients: the difference of serum vitamin D level and MoCA score between non-PDD early and late groups was not statistically significant (P>0.05).5.There was no significant correlation between serum vitamin D level and cognitive domains of MoCA in PDD patients, whereas there was a positive correlation between serum vitamin D level and naming ability of MoCA in non-PDD patients.

Conclusions: 1.The decrease of serum vitamin D level may be one of the mechanisms for the occurrence of PD and the decline of cognitive function. 2.There is a positive correlation between serum vitamin D level and the naming ability of MoCA in non-PDD patients .3.For PD patients with cognitive impairment, especially in the early stage of PDD,if given the relevant intervention may be of great significance.

References: [1] Cosgrove J, Alty JE, Jamieson S. Cognitive impairment in Parkinson’sdisease[J]. PostgradMed J, 2015, 91(1074): 212-220. [2] Hindle J V. The practical management of cognitive impairment and psychosis in the older Parkinson’s disease patient[J]. Journal of Neural Transmission, 2013, 120(4):649-653. [3] Goldman J G, Holden S. Treatment of psychosis and dementia in Parkinson’s disease[J]. Current Treatment Options in Neurology, 2014, 16(3):281.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/study-on-correlation-between-serum-vitamin-d-level-and-cognition-of-parkinsons-disease/