Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Neuroimaging and neurophysiology
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To determine the prevalence of increased echogenicity in the substantia nigra in patients diagnosed with idiopathic Parkinson’s disease at the University Hospital "Dr. José Eleuterio González ".
Background: Introduction: Parkinson’s disease is the second most common progressive neurodegenerative disease of adult onset and the second movement disorder. Substantia nigra (SN) hyperechogenicity is a biomarker for Parkinson’s disease (PD). This is a SN hyperechogenicity measure by transcranial ultrasound in a cohort of patients with PD in North of Mexico.
Methods: Methods: This is a cross-sectional study, SN hyperechogenicity was evaluate in 35 patients with diagnosis of Parkinson’s disease, from the Parkinson´s Disease and Movement Disorder Clinic University Hospital "Dr. José Eleuterio González ". Midbrain of each patient were visualized by transcranial ultrasound following and standardized protocol.
Results: The substantia nigra was assessable in 92% of all participants, in 2 (5.6%) the study was negative. We confirmed that SN echogenicity is significantly increased in PD patients, 30 patients (85.7%) were found an increased echogenicity in the topography of the substantia nigra (larger of bilateral measurement) of the midbrain level ≥ 0.19cm2, there were not correlated with age. We concluded a study as positive only with having observed the alteration of the substantia nigra unilaterally in the midbrain peduncle.
Conclusions: This study indicates the merit of manual measurement of SN hyperechogenicity by transcranial sonography in PD diagnosis in Mexican patients and demonstrates that transcranial sonography of the substantia nigra is a relevant and useful diagnostic tool for patients with PD. As best of we know this first study that concluded a study as positive only with having observed the alteration of the substantia nigra unilaterally in the midbrain peduncle, although the contralateral peduncle for some reason could not be displayed.
It was presented as a thesis project for the degree of Radiologist.
To cite this abstract in AMA style:
C.Y. Rodriguez-Garza, A. Anaya-Escamilla, R. Pinales-Razo, I. Estrada-Bellmann, C.R. Camara-Lemarroy. Substantia nigra hyperechogenicity in Mexican patients with Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/substantia-nigra-hyperechogenicity-in-mexican-patients-with-parkinsons-disease/. Accessed May 13, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/substantia-nigra-hyperechogenicity-in-mexican-patients-with-parkinsons-disease/