Session Information
Date: Monday, October 8, 2018
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: To compare the differences of clinical characteristics between PD patients with rapid eye movement sleep behavior disorder (RBD) (RBD+ group) and those without RBD (RBD- group). To explore new ideas for the study of pathogenesis, early diagnosis and treatment of PD.
Background: The clinical features of PD patients with RBD were different from those without RBD, suggesting that PD may have different clinical subtypes.
Methods: In this cohort study, 53 patients with primary PD were enrolled. The PD patients with RBD were further divided into ERBD group and LRBD group according to the medical history. The statistical methods were used to compare the motor symptoms, cognitive function, anxiety and depression, the prevalence rate of obstructive sleep apnea symptom (OSAS), sleep parameters and sleep structure among groups.
Results: 1.The motor symptoms, cognitive function, depression and anxiety of PD patients with RBD were more serious than those without RBD. 2.The REM sleep time of PD patients with RBD was longer than that in PD patients without RBD, while the prevalence rate of OSAS of PD patients with RBD was lower than that in PD patients without RBD. 3.Compared with the patients whose RBD symptoms prior to PD, those RBD symptoms’ occuring at the same time as PD or secondary to PD showed more serious motor symptoms, shorter sleep time of REM and more resistance to anti-PD drugs. 4.The patients whose RBD symptoms’ occuring at the same time as PD or secondary to PD were younger than those RBD symptoms prior to PD. The sleep time of REM for the patients with RBD symptoms prior to PD was longer than that of PD patients without RBD.
Conclusions: 1.Cognitive protection and psychological intervention should be taken early for PD patients with RBD. 2.RBD might be a protective factor for OSAS. Continuous positive airway pressure should be applied early for the PD patients without RBD who were combined with OSAS to improve the chronic hypoxia in patients. 3.The prognosis of patients with RBD symptoms prior to PD is better. 4.PD might have different clinical subtypes in terms of pathogenesis.
To cite this abstract in AMA style:
Y. Wang, Z. Liang. The Clinical Research of Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/the-clinical-research-of-parkinsons-disease-with-rapid-eye-movement-sleep-behavior-disorder/. Accessed June 14, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-clinical-research-of-parkinsons-disease-with-rapid-eye-movement-sleep-behavior-disorder/