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The effect of active contact localization on motor symptoms in deep brain stimulation of the subthalamic nucleus for Parkinson’s disease

T. Ten Brinke, V. Odekerken, P. Schuurman, R. de Bie (Amsterdam, Netherlands)

Meeting: 2019 International Congress

Abstract Number: 1112

Keywords: Deep brain stimulation (DBS)

Session Information

Date: Tuesday, September 24, 2019

Session Title: Parkinsonisms and Parkinson-Plus

Session Time: 1:45pm-3:15pm

Location: Agora 3 West, Level 3

Objective: To evaluate whether implantation precision is related to the outcome of STN DBS.

Background: Accurate implantation of electrodes is important for the outcome of deep brain stimulation (DBS) treatment of Parkinson’s disease (PD). There is a need for data on the value of implantation precision.

Method: Hemibody data from STN DBS patients were divided into responders and non-responders based on the post-operative improvement on the UPDRS-III hemibody score. A Euclidean distance from the individual active contact points to the mean of all active contacts points was compared between responders and non-responders.

Results: Full data was available for 83 electrodes. The mean coordinates of the responders did not differ from the mean coordinates of the non-responders. The distance from the active contact to the mean of all active contacts was 2.2±1.1 mm (mean±SD) in the responder group and 3.2±1.4 mm in the non-responder group (p = 0.001).

Conclusion: No unidirectional targeting error was found to be related to clinical response. Increased random error (less precision) was associated with less clinical response.

To cite this abstract in AMA style:

T. Ten Brinke, V. Odekerken, P. Schuurman, R. de Bie. The effect of active contact localization on motor symptoms in deep brain stimulation of the subthalamic nucleus for Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/the-effect-of-active-contact-localization-on-motor-symptoms-in-deep-brain-stimulation-of-the-subthalamic-nucleus-for-parkinsons-disease/. Accessed July 12, 2025.
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