Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To examine relationship between olfactory dysfunction and PD-MCI, and investigated the patterns of olfactory function in subtypes of PD-MCI patients using the Korean version of the Sniffin’ stick test II (KVSS II).
Background: The evaluation of olfactory function is a valuable marker for the detection of parkinsonism prior to motor symptoms and for the early diagnosis of various degenerative dementias. Parkinson’s disease (PD) patients have an increased risk of associated dementia and one-third of patients with PD have mild cognitive impairment (MCI) at the time of diagnosis. However, the characteristics of olfactory dysfunction in PD-MCI patients have not been well investigated.
Methods: A total of 106 drug-naïve PD patients were enrolled in the study. We performed a neuropsychiatric battery to assess cognitive status and sub-classified the types of cognitive impairment into four categories. Olfactory dysfunction was examined by KVSS II. For the statistical analysis, multivariable linear regression and multiple logistic regression analysis were used to determine the relationship between the variables and olfactory function.
Results: Olfactory dysfunction was more prevalent in the PD-MCI group than in the PD-normal cognition group. Olfactory threshold and odor discrimination was more impaired in the PD-MCI group as compared with the PD-normal cognition group. Among PD-MCI subgroups, patients with multiple domains of cognitive impairment were more associated with olfactory dysfunction than patients with a single domain of cognitive impairment.
Conclusions: In our study, we concluded that PD-MCI patients were more likely to be associated with olfactory dysfunction compared to PD-normal cognition patients. We hypothesized that there may be more extensive neurodegenerative processes affecting olfaction in PD-MCI patients. With further investigation and validation using neuropathological data, an objective olfactory function test could be used as a tool to evaluate disease progression. Further studies investigating the prognostic value of olfactory dysfunction in PD-MCI patients are essential.
To cite this abstract in AMA style:J.W. Park, H.K. Yoon, M.H. Park, D.Y. Kwon. The patterns of olfactory function in Parksinson’s disease patients with mild cognitive impairment [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-patterns-of-olfactory-function-in-parksinsons-disease-patients-with-mild-cognitive-impairment/. Accessed February 21, 2024.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-patterns-of-olfactory-function-in-parksinsons-disease-patients-with-mild-cognitive-impairment/