Objective: The application of Duodopa in advanced Parkinson Disease (aPD) is quite new in the world and in Turkey. The main goal is to treat unbearable motor signs and complications of medications. But most of the time, non-motor findings and autonomic disregulations are often overlooked. Whereas, not only motor problems but also non – motor and especially autonomic finding are very tough issue in eldery and advanced PD cases. Unfortunately, there is no specific evaluation scales or guidelines for only non – motor and autonomic mutual effects.

Background: Therefore, it is aimed to investigate the effect of DUODOPA on non – motor and autonomous system which has entered into application in advanced PH in recent years. The best way for evaluating the non – motor symptoms and autonomic dysfuntions is done with UPDRS and also with clinical observations. Since the concept of non – motor and autonomic dysfunctions is very important in quality of Life of aPD patients.

Methods: From Turkey, at two centers – Selçuk University, Konya and Erciyes University, Kayseri, School of Medicine, Department of Neurology, Movement Disorders Unit were participated in this study. A total number of 22 with aPD who were treated with DUODOPA in between 2014 to 2018 were evaluated. The clinical course of these patients with 3-month follow-up was investigated. Non motor symptoms and autonomic findings – constipation, urinary retention, frequency, orthostatic hypotension, excessive sweating, sexual dysfunction, hypersexuality, sleep disorders, REM sleep behavior disorders, restless leg syndrome etc. were examined. The effects of DUODOPA on these manners were investigated with UPDRS scores just before the application in “On” or “Off” period of patient and also after the Gel Dopa in different time periods.

Results: There were significant discrete reduction in antipsychotic usages and the best changes were observed in REM sleep behavior disorders, daytime sleepiness and autonomic involvement in orthostatic hypotension and hypersalivation. The latter were nonsignificant statistically. The results were evaluated and collected with UPDRS scores either “on” or “decreased off periods”. Each subtitle of non motor and autonomic signs was compared just before and after the DUODOPA treatment.

Conclusions: We can say DUODOPA treatment in advanced PD is very important for improvement of non – motor symptoms and especially autonomic system dysfuntions.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-role-of-duodopa-treatment-on-non-motor-symptoms-specificly-autonomic-dysfunctions/