Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The aim of this study was to assess the motor and psychiatric outcomes at 6 months after subthalamic nucleus deep brain stimulation (STN-DBS) in advanced idiopathic Parkinson’s disease.
Background: Deep brain stimulation in substantial nigra (STN-DBS) in a surgical treatment of choice for levodopa-responsive idiopathic Parkinson’s disease with motor complication.
Methods: We retrospectively reviewed the clinical data of the advanced Parkinson’s disease (PD) patients who underwent STN-DBS at Prasat Neurological Institute during 2013-2015. Baseline assessment at pre-operative period included clinical assessment using The Unified Parkinson’s disease Rating Scale (UPDRS) part I-IV, cognitive functions using Thai Mental State examination (TMSE) and Montreal Cognitive Assessment (MoCA), and psychiatric evaluation for anxiety using Hamilton Anxiety Rating Scale (HAM-A) and depression using HAM-D. Re-assessment with the same tests was undertaken at 6 months after the surgery.
Results: Twelve patients receiving bilateral STN-DBS and one patient receiving unilateral STN- DBS were enrolled. The average levodopa challenge test was reduced 48.65 percent at the baseline. The UPDRS showed significant improvement in all domains (I-IV) at 6 months after the surgery. The levodopa equivalent dose (LED) was also significantly reduced for 24.66 percent. Regarding cognitive and psychiatric assessment after the surgery, decreased TMSE and decreased HAM-A scores were noted, whereas MoCA and HAM-D remained unchanged.
Conclusions: Similar with previous literatures, the score of all UPDRS domains, particularly in part III motor functions, were significantly improved after STN-DBS. The LED was also decreased and this resulted in better control of dyskinesic symptom. Significant reduced TMSE score reflecting poorer cognitive function after the surgery was noted in our study. In the current context of unestablished clinical or laboratory markers in predicting post-operative cognitive decline after STN-DBS, careful patient selection is deemed to be important.
To cite this abstract in AMA style:
P. Papitak, M. Aphiwatthanakun, T. Srikijvilaikul, N. Limotai. The study of clinical outcome of deep brain stimulation for the idiopathic Parkinson’s disease at 6 months follow-up [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-study-of-clinical-outcome-of-deep-brain-stimulation-for-the-idiopathic-parkinsons-disease-at-6-months-follow-up/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-study-of-clinical-outcome-of-deep-brain-stimulation-for-the-idiopathic-parkinsons-disease-at-6-months-follow-up/