Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To our knowledge, no studies have examined whether the lymphoid tissue of the tonsils are involved PD, or whether tonsillectomy modifies the risk of PD.
Background: Recent research suggests that PD may be a prion-like disease. Lymphoid tissues of the tonsils play a central part in transmissible prion diseases, like variant Creutzfeldt-Jakob disease.
Methods: We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980-2010 (n= 195,169) and a matched age and sex general population comparison cohort (n= 975,845). Patients were followed until diagnosis of PD (ascertained by in- and outpatient hospital diagnoses) death, censoring, or end of follow-up Nov 30th 2013. Using Cox regression, we computed hazard ratios (HRs) for PD and corresponding 95% confidence intervals (CIs), adjusting for age and sex by study design, together with other potential confounders, stratified by follow-up time and sex.
Results: During follow-up, we identified 100 and 568 PD diagnoses amongst the tonsillectomy cohort and the general population comparison cohort, respectively, finding an almost similar risk of PD [adjusted (a) HR = 0.95 (95% CI: 0.76–1.19)]. No substantial difference was observed after more than 20 years of follow up (HR= 0.96 (95% CI: 0.64–1.41). There was no difference stratifying on sex.
Conclusions: Tonsillectomy is not a risk factor for PD.
To cite this abstract in AMA style:E. Svensson, V. Henderson, S. Szépligeti, M. Stokholm, T. Klug, H. Sørensen, P. Borghammer. Tonsillectomy and risk of Parkinson’s disease: A Danish nationwide population-based cohort study [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/tonsillectomy-and-risk-of-parkinsons-disease-a-danish-nationwide-population-based-cohort-study/. Accessed December 1, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/tonsillectomy-and-risk-of-parkinsons-disease-a-danish-nationwide-population-based-cohort-study/