MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Transcriptome modification of anodal transcranial direct current stimulation in transgenic Parkinson’s disease mouse model

W. Jang, H-T. Kim (Seoul, Republic of Korea)

Meeting: 2019 International Congress

Abstract Number: 2107

Keywords: Mitochondrial DNA(mtDNA), Parkinsonism

Session Information

Date: Wednesday, September 25, 2019

Session Title: Non-Pharmacological Interventions

Session Time: 1:15pm-2:45pm

Location: Les Muses Terrace, Level 3

Objective: We tried to investigate the impact of tDCS on mRNA and microRNA expression in striatum and substantia nigra of transgenic mouse model of PD.

Background: Transcranial direct current stimulation (tDCS) has demonstrated to modulate neuroplasticity and its beneficial effects of motor and non motor symptoms are observed in PD patients. Furthermore, recently, some results showed neuroprotective effect in PD in vivo model. However, few studies have attempted to elucidate the underlying molecular mechanisms of tDCS in the brain

Method: As transgenic mouse model of PD, we adopted α-synuclein A30P/A53T double mutation mouse. Anodal tDCS was applied as stimulation method at 1.5mA intensities for 5 consecutive sessions over 1 week. Mouse group was divided into tDCS and control group. After the last tDCS was applied, all of the mice were tested on the motor coordination test and then sacrificed followed by performing microarray for evaluation of microRNA(miRNA) and mRNA transcriptome and analysis.

Results: In striatum, 38 miRNA and 39 mRNA probes were detected as significant (|Fold change|≥1.5 & p <0.05) and 29 miRNA and 274 mRNA probes showed significant difference in SN. In a functional annotation, a variety of cellular processes, biological processes, and molecular categories in SN and striatum were found to be modified by anodal tDCS compared to control group. KEGG analysis show that melanogenesis, pathway in cancer, cushing’s syndrome, cAMP signaling pathway, cGMP-PKG signaling pathway, Vascular mooth muscle contraction and inflammatory mediator regulation of TRP channels were most affected. (p < 0.001). We also investigated correlation between microRNA and mRNA. In SN, 3 miRNA were upregulated with concomitant mRNA downregulation (miR-30c-2-3p, miR-7a-2-3p, miR-676-3p) and 2 miRNA were downregulated in parallel with mRNA upregulation (miR-1906, miR-466f-3p), while 8 miRNA were detected as significant for correlation with mRNA expression in striatum (miR-101a-5p, miR-134-5p, miR-143-3p, miR-16-2-3p, miR-361-5p, miR-532-3p, miR-665-5p, miR-1934-3p)

Conclusion: Our results support anodal tDCS can modify the expression of transcriptome profiles and elucidate some specific pathway could be involved as mechanism of tDCS.

To cite this abstract in AMA style:

W. Jang, H-T. Kim. Transcriptome modification of anodal transcranial direct current stimulation in transgenic Parkinson’s disease mouse model [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/transcriptome-modification-of-anodal-transcranial-direct-current-stimulation-in-transgenic-parkinsons-disease-mouse-model/. Accessed May 13, 2025.
  • Tweet
  • Email
  • Print

« Back to 2019 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/transcriptome-modification-of-anodal-transcranial-direct-current-stimulation-in-transgenic-parkinsons-disease-mouse-model/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • The hardest symptoms that bother patients with Parkinson's disease
  • Life expectancy with and without Parkinson’s disease in the general population
  • Patients with Essential Tremor Live Longer than their Relatives
  • #23624 (not found)
  • The hardest symptoms that bother patients with Parkinson's disease
  • Three cases of early tremor in the course of Guillain-Barré Syndrome
  • The impact of gastric acid suppressants and antacids on levodopa plasma concentration in patients with Parkinson’s disease
  • To be or not to bupropion: a drug-induced parkinsonism?
  • The Role of MRI and DaTscan in Vascular Parkinsonism: A Case Report
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley