Oral apomorphine film (APL-130277) produces no buccal mucosal irritation: Results of a toxicological study
Objective: Determine the tolerance of and potential for cheek pouch buccal mucosa irritation following the administration of apomorphine film (APL-130277). Background: APL-130277 is a sublingual…Differential vulnerability to α-synuclein pathology among neuronal subpopulations
Objective: To identify the cell death pathway(s) activated by α-synuclein (α-syn) pathology in an in vitro model of Lewy pathology and determine if neuronal subpopulations…Generation and characterization of midbrain organoids from iPSCs of familial Parkinson’s disease
Objective: To generate and characterize human pluripotent stem cell (iPSCs) - derived midbrain cerebral organoids of patients with Parkinson's disease. Background: Parkinson's disease is a…Phosphorylation by GSK-3β enhances binding of metal ion induced tau oligomers to neutral lipid surfaces
Objective: To dissect the complex interplay of tau hyperphosphorylation, metal ion induced oligomer formation and membrane interactions applying single particle fluorescence techniques. Background: Fibrillar deposits…Endoscopically-documented pharyngeal dystonia due to neuroleptic use without response to alcohol
Objective: To review a case of endoscopically-documented pharyngeal dystonia and its response to alcohol. Background: Pharyngeal dystonia is a rare complication of neuroleptic use, resulting…Symptomatic palatal and respiratory tremor with ataxia following fourth ventricle epidermoid cyst removal
Objective: Present rare cause of symptomatic palatal tremor and ataxia after fourth ventricle cyst removal with unusual respiratory muscle involvement. Background: Symptomatic palatal tremor (SPT)…Systematic review and meta-analysis of randomized controlled trials to evaluate placebo response in restless legs syndrome
Objective: To quantify the magnitude of the placebo response in restless legs syndrome (RLS). Background: RLS is a common sensorimotor disorder characterized by an urge…The inflammatory burden of tic onset in a paediatric cohort: A preliminary study
Objective: To evaluate the role of inflammatory triggering factors in the onset of tics and Tourette syndrome in a prospective cohort of paediatric population. Background:…Using wavelet coherence analysis to distinguish between tremor types
Objective: To distinguish between types of tremor using wavelet coherence analysis. Background: To discriminate between tremor types can be challenging in clinical practice. Standard electromyographic…Resetting tremor by single pulse transcranial magnetic stimulation at the motor cortex and the cerebellum in essential tremor and dystonic tremor
Objective: To explore the role of M1 and CB in the pathophysiology of ET and DT by assessing tremor resetting with motor cortex (M1) and…
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