PARK-OMM – An osteopathic manipulative medicine protocol to improve motor function and balance in Parkinson’s disease
Objective: To evaluate the effects of a pre-defined Osteopathic Manipulative Medicine (OMM) treatment protocol (PARK-OMM) for 6 weeks compared to a 6-week controlled counseling period…Pathological findings from two Parkinson’s disease patients after intraputaminal GDNF infusion
Objective: To describe the postmortem findings from two patients who underwent intraputaminal infusion of glial-derived neurotrophic factor (GDNF). Background: GDNF has been shown to have…Clinical effect and dose conversion of rytary (numient) in 50 consecutive patients with PD motor fluctuations
Objective: To review the clinical use of a newer extended-release levodopa preparation in 50 consecutive patients with PD experiencing motor fluctuations on immediate-release levodopa. Background:…Effects of the biodex stability system training on balance, gait and fatigue in Parkinson’s disease
Objective: The purpose of this study was to evaluate the effects of 4 weeks of BSS training on balance, gait and fatigue in PD patients.…Multi-modal recruitment strategy leads to expeditious enrollment in STEADY-PD III
Objective: To review a successful multi-modal recruitment strategy in a clinical trial of early untreated PD patients. Background: STEADY-PD III is a multicenter NINDS funded…A healthy volunteer phase 1 study of RE-024, a potential phosphopantothenate replacement therapy for patients with pantothenate kinase-associated neurodegeneration (PKAN)
Objective: To assess the safety, tolerability, and pharmacokinetics of single oral doses of RE-024 in healthy adult volunteers. Background: PKAN is a rare, autosomal recessive,…Distribution of oscillatory activities in MRI confirmed subthalamic nucleus subregions
Objective: To explore the differences and similarities of oscillatory activity between subregions of the subthalamic nucleus (STN). Background: In Parkinson's disease (PD), treatment driven changes…Upregulated vascular endothelial nitric oxide synthase in Parkinson’s disease cases that have received subthalamic stimulation: A post-mortem evaluation
Objective: Here we measured levels of vascular endothelial nitric oxide synthase (eNOS) expression as a result of high frequency (HF) Deep Brain Stimulation (DBS) of…Strengths and weaknesses of patient-reported outcomes following DBS surgery: Comparing clinician, patient, and caregiver assessments
Objective: Assess the degree of correlation between DBS outcome measures rated by patients, caregivers, and clinicians. Methods: The Clinician Global Impression (CGI) score and two…The long-term follow-up of subthalamic nucleus deep brain stimulation comparing medication alone in advanced Parkinson’s disease patients
Objective: To investigate whether advanced Parkinson's disease (PD) patients receive subthalamic nucleus deep brain stimulation (STN-DBS) or medical treatment alone have different long-term outcome. Background:…
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