Cell-surface expression of dopamine transporter facilitates the uptake of α-synuclein
Objective: We determined whether increased expression of DAT have an impact on the uptake of α-synuclein (αS). Background: The endocytosis of dopamine transporter (DAT) controls…Role of dopamine and GABA during subthalamic and pallidal deep brain stimulation: Evidence of dopamine release during subthalamic Deep Brain Stimulation
Objective: We recorded the single-unit activity of striatal cholinergic interneurons of healthy monkeys during high-frequency stimulation (HFS) of the subthalamic nucleus (STN) and globus pallidus…Associations between cerebrospinal fluid proteins and cytokines in Parkinson’s disease
Objective: To investigate the relationship between cerebrospinal fluid (CSF) proteins and cytokines, and their correlation with clinical measures in PD. Background: Several studies have investigated…The small GTP-binding protein Rhes influences midbrain dopaminergic neurons: Behavioral and biochemical studies
Objective: Rhes is a small GTP-binding protein highly enriched in the striatum, developmentally regulated by thyroid hormone, and by dopamine (DA) innervation in adult rat…Parkinson’s disease onset on non-dominant side predicts greater motor disability
Objective: Evaluate (1) the effect of dominant-side onset (DSO) vs non-dominant-side onset (NDSO) of Parkinson's disease (PD) on motor impairment in a large multicenter cohort…Mitochondrial Hsp90 inhibitor G-TTP triggers PINK1/parkin-dependent mitochondrial quality control
Objective: To characterize the response of cells treated with Gamitrinib-triphenylphosphonium (G-TTP) a mitochondrial targeted inhibitor of the chaperone Hsp90. Background: Upon dissipation of the mitochondrial…ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways
Objective: Endosomal sorting required for transport (ESCRT) orchestrates endo-lysosomal soring of ubiquitinated proteins, multivesicular body formation. The aim of this study is to elucidate the…Persistent drug-induced parkinsonism with normal dopamine transporter imaging
Objective: We investigated whether patients with persistent drug-induced parkinsonism (DIP) showing visually normal dopamine transporter (DAT) imaging had minimal changes in striatal DAT activity using…Topiramate responsive adult-onset opsoclonus myoclonus ataxia syndrome
Objective: Opsoclonus myoclonus ataxia (OMA) is a rare neurological syndrome characterized with with autoimmune background. However the exact pathophysiology is not clear. Most common underlying…Prevalence of restless legs syndrome in an atypical Parkinson’s disease population
Objective: The aim of this study was to determine the prevalence of Restless Legs Syndrome (RLS) in patients with Multiple Systems Atrophy (MSA), Corticobasilar Degeneration…
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