Pharmacokinetic-pharmacodynamic effects of apomorphine sublingual film (APL-130277) for the rapid management of OFF episodes in patients with Parkinson’s disease
Objective: Determine the pharmacokinetic/pharmacodynamic effects of APL-130277 on OFF episodes in patients with Parkinson's disease (PD). Background: APL-130277 is a sublingual film being studied in…DJ-1 regulates intracellular signaling in a highly cell type specific manner
Objective: To evaluate a cell type specific action of DJ-1, a PD and cancer associated gene, in intracellular signaling pathways. Background: Understanding the pathophysiology of…Association of Parkinson’s disease severity and cortical and subcortical cognitive markers
Objective: To assess cortical and subcortical dysfunction in several stages of Parkinson's disease (PD) using the Parkinson's disease-cognitive rating scale (PD-CRS). Background: Cognitive impairment in…Manganese-induced parkinsonism and motor neuron damage- Can there be a relationship?
Objective: The aim of the study was evaluation of clinical, radiological and ENMG characteristic of ephedronic encephalopathy(EE). Background: The ephedrone abuse is widely spread among…Fahr’s syndrome in a Filipino female with hearing loss and polycystic ovaries: A case report
Objective: The objective of this case report is to document a case of Fahr's syndrome including its varied clinical manifestations. Background: Idiopathic basal ganglia calcification,…A peripheral pathway to restless legs syndrome? Clues from familial amyloid polyneuropathy
Objective: To investigated if RLS is increased in familial amyloid polyneuropathy related to transthyretin (TTR-FAP) and to identify factors associated with RLS in this population.…SPAsticity in PractiCE (SPACE) – An international, observational study of botulinum toxin type A in spasticity
Objective: To collect real-world routine clinical practice data on effectiveness, safety, and quality of life (QoL) for botulinum toxin type A (BoNT-A) treatment of focal…Long-term responsive deep brain stimulation in Tourette syndrome
Objective: To develop and measure the effectiveness of responsive deep brain stimulation for the treatment of Tourette syndrome. Background: Tourette's Syndrome (TS) is a paroxysmal…Sleep in essential tremor patients: A polysomnographic study
Objective: The aim is to investigate sleep and sleep related disorders in essential tremor patients compared with Parkinson's disease patients and healthy control subjects. Background:…Re-emergent tremor in Parkinson’s disease: Epidemiological and clinical features
Objective: To evaluate the prevalence and the clinical features of re-emergent tremor (RET) in a large sample of consecutive patients with Parkinson's disease (PD) and…
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