A clinical trials ‘charter’ to improve communication about, recruitment to and retention in Parkinson’s clinical trials
Objective: The objective of the project was to design a durable tool, usable by clinical trial investigators and participants alike, that would improve subject retention…Global implementation of efficacious voice treatment for Parkinson’s disease: LSVT LOUD: Germany®
Objective: This project was designed to evaluate the implementation of an efficacious voice treatment (LSVT LOUD) developed in the USA and designed to improve speech…RE-024: A potential phosphopantothenate replacement therapy in 2 patients with pantothenate kinase-associated neurodegeneration (PKAN)
Objective: To evaluate the safety and potential efficacy of RE-024 in open treatment of 2 patients with PKAN. Background: PKAN is an autosomal recessive, neurodegenerative…Chronic directional subthalamic nucleus deep brain stimulation in Parkinson’s disease – A pilot study
Objective: This pilot study aimed to assess the therapeutic potential of chronically implanted directional DBS leads in patients with Parkinson's disease. Background: The therapeutic effect…Clinical characteristics of Parkinson’s disease and essential tremor patients undergoing deep brain stimulation surgery: Five-year data from Columbia University Medical Center (2009 – 2014)
Objective: To compare the clinical characteristics of essential tremor (ET) and Parkinson's disease (PD) patients who underwent deep brain stimulation (DBS) surgery to those of…Identification of unique metabolite signatures in post-mortem DBS human tissue using LC-HRMS
Objective: Metabolomics is applied to the study of metabolic as well as neurodegenerative diseases. We propose to utilize this technique to detect metabolic changes from…Neurophysiological assessment of corticospinal tract activation due to subthalamic deep brain stimulation in patients with Parkinson’s disease
Objective: To assess current spread to the corticospinal tract (CST) in patients with Parkinson's disease (PD) treated with bilateral Deep Brain Stimulation (DBS) of the…Speech 10 years post bilateral STN-DBS for Parkinson’s disease
Objective: This study reports on the type and severity of speech problems up to 10 years after bilateral deep brain stimulation (DBS) of the subthalamic…Neuropsychological safety of bilateral pallidal (GPi) deep brain stimulation (DBS) for Parkinson’s disease (PD) under general anesthesia
Objective: To evaluate neuropsychological outcome of bilateral GPi DBS carried out under general anesthesia using a combination of direct anatomical targeting and intraoperative computed tomography…Clinical outcome of constant current deep brain stimulation in patients with medication-refractory essential tremor
Objective: To evaluate, for the first time, the safety and efficacy of long-term ventralis intermedius (Vim) constant current deep brain stimulation (DBS) in essential tremor…
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