Physical training prevents depressive-like behavior and bdnf decrease in an animal model of Parkinson’s disease
Objective: The aim of this study was to investigate the effects of two types of physical training on depressive-like behavior and pro-BDNF, BDNF and its…Glatiramir acetate (Copaxone) causes restoration of the striatal dopamine in a progressive MPTP mouse model of Parkinson’s disease
Objective: To assess if a microglial modulator, Glatiramer Acetate (GA), can restore loss of striatal dopamine (DA) and behavioral deficits following progressive 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)…Dissecting the molecular mechanisms of Fyn-mediated levodopa induced dyskinesias
Objective: To investigate the crosstalk between D1 receptor (D1R) and the signaling of Fyn protein kinase in a mice model of levodopa (L-DOPA) induced dyskinesias…Constipation in early de novo Parkinson’s disease: Prevalence and correlates with clinical features, imaging and non-imaging biomarkers
Objective: To explore the association between constipation and clinical features, imaging and non-imaging biomarkers in early de novo (untreated) Parkinson's disease (PD) patients. Background: Constipation…Floor square size predicts step count of 360° turns in PD patients with freezing
Objective: To determine the effect of floor square size on turning behavior in patients with PD. Background: Turning has been repeatedly shown to be the…Gender-age features of autonomic heart rhythm disturbances in Parkinson’s disease patients
Objective: To determine the gender differences and age-dependent features of autonomic heart rhythm disturbances in patients with Parkinson's disease (PD). Background: Autonomic heart rate failures…Treatment of OFF episodes in Parkinson’s disease: An evaluation of physician practices
Objective: Determine physician practices into the treatment of OFF episodes in patients with Parkinson's disease PD. Background: OFF episodes are fairly common in patients with…The effects of viral priming on neurotoxin induced neurodegeneration and synapse dysfunction in cell culture models relevant to Parkinson’s disease
Objective: To investigate the effects of viral innate immune activation on neurodegeneration and synaptic protein expression in dopaminergic (DA)-like neurons following treatment with Parkinson's disease…Exosomes-injection to reproduce a mouse model of Parkinson’s disease: A preliminary report
Objective: To explore the pathogenicity of exosomes derived from Parkinson's disease (PD) patients' serum and healthy control's serum in vivo and verify the prion-like propagation…Increased cellular co-localization of tau fragment 1-368 and alpha-synuclein in two mouse model of Parkinson’s disease
Objective: To examine the distribution of a novel tau pathology and its interaction with alpha-synuclein in two mouse model of Parkinson's disease (PD). Background: Cleavage…
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