Correlation analysis for postural instability and autonomic dysfunction in patients with Parkinson’s disease
Objective: To investigate correlation between postural instability and autonomic dysfunction in early stage Parkinson's disease patients. Background: Brainstem pathology may link postural instability (PI) and…When and why patients with Parkinson’s disease become bed ridden
Objective: To elucidate the influence of age, disease duration, and complicated medical and social conditions as the risk factors to predict disease progression. To this…Diagnostic value of a new coronal examination plane in transcranial nigral sonography and of additional M-mode tremor frequency determination for the differentiation of idiopathic Parkinson’s disease and essential tremor
Objective: To (1) evaluate a new coronal examination plane in comparison to the established axial examination plane for detection of nigral hyperechogenicity and (2) to…Impaired cerebellum to motor cortex associative plasticity in Parkinson’s disease
Objective: To compare the corticocortical paired associative stimulation (PAS)-induced spike-timing dependent plasticity (STDP)-like plasticity between Parkinson's disease (PD) and healthy elder subjects. Background: Patients with…Pain-motor integration in the primary motor cortex in Parkinson’s disease
Objective: To investigate pain-motor integration experimentally in patients with Parkinson's disease (PD), with and without chronic pain. Background: Although chronic pain is a common non-motor…Combined effects of visual and auditory cues on gait initiation in Parkinson’s disease
Objective: To investigate the combined effects of visual and auditory cues on gait initiation and to investigate the correlation between the clinical rates of gait…Novel PET Tracers of alpha-synuclein for the diagnosis of Parkinson’s disease
Objective: The aim of our project is to develop small molecular weight compounds (Morphomers™) which bind selectively to alpha-synuclein (aSyn) aggregates, in order to generate…DTI in Parkinson’s disease: Asymmetric progression
Objective: To study the rate of change of brain region diffusion tensor imaging (DTI) parameters between the right and left sides in PD patients using…Critical path for Parkinson’s II: Global regulatory agencies support the use of dopamine transporter neuroimaging as an enrichment biomarker to enable clinical trials in early Parkinson’s disease
Objective: This presentation focuses on neuroimaging of the Dopamine Transporter as an enrichment biomarker in clinical trials of Parkinson's disease (PD). Background: The Critical Path…A longitudinal study of functional deterioration of primary olfactory cortex in early-stage Parkinson’s disease
Objective: To study the dynamic changes of the olfactory cortex function in the early-stage Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI). Background: Olfactory…
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