Clinically ‘slight’ bradykinesia in Parkinson’s disease is accurately detected using evolutionary computation analysis of finger tapping
Objective: To assess whether MDS-UPDRS grade one Parkinson's disease (PD) bradykinesia can be accurately detected by a novel non-invasive device that analyses a standard finger…Evaluation of kinematic parameters of potential clinical use extracted from Microsoft Kinect V2 motor assessments
Objective: To evaluate movement parameters for clinical use extracted from Microsoft Kinect V2 joints. Background: Instrumental motor assessment has been proposed to increase objectivity but…The relevance of movement disorders gene panels in clinical practice: How many patients are we sorting out?
Objective: To investigate the impact of movement disorder gene panels in clinical practice and the proportion of patients receiving a definite genetic diagnosis through Next…The distinguishing clinical features of rapid-onset-parkinson-dystonia (RDP) syndrome due to ATP1A3 mutations
Objective: To determine characteristics that distinguish individuals with presentation suggestive of RDP in ATP1A3 mutation carriers compared with non-carriers. Background: Mutations in the ATP1A3 gene…Alpha-synuclein levels and dimerization in erythrocytes of Parkinson’s disease patients
Objective: To identify possible differences in monomeric/dimeric α-synuclein levels in erythrocytes derived from PD patients from different genetic backgrounds, and check for potential links between…The Faroese Parkinson’s diseases research program-Multifactorial analyses of a complex syndrome
Objective: The program aim is to assess the contribution of genes and environment influencing susceptibility, progression and the relative contribution of risk factors underlying Parkinson's…Do mutations in the TGM6 (SCA35) gene cause early-onset Parkinson’s disease?
Objective: To identify the genetic cause of early-onset Parkinson's disease (EOPD) in a Serbian family. Background: Hereditary EOPD is a genetically heterogeneous neurodegenerative disorder, characterized…Deletions at 22q11.2 in idiopathic Parkinson’s disease: A combined analysis of GWAS data
Objective: To verify the reported association of Parkinson's disease(PD) with Chromosome 22q11.2 Deletion Syndrome(22q11.2DS) in series of large, independent idiopathic PD case-control studies. Background: PD…Levodopa-responsive hereditary spastic paraplegia, SPG35, due to FA2H mutations in siblings
Objective: To describe FA2H mutations, one novel, in siblings with SPG35 with symptoms responsive to levodopa. Background: Hereditary spastic paraplegia (HSP) is a phenotypically and…Two-step induction of dopaminergic neurons – Differentiation of leukapharesis-derived mesenchymal stem cells
Objective: The aim of the present study is to establish a reproducible in-vitro protocol to induce the human MSCs derived from peripheral blood, after mobilization…
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