Multi-modal recruitment strategy leads to expeditious enrollment in STEADY-PD III
Objective: To review a successful multi-modal recruitment strategy in a clinical trial of early untreated PD patients. Background: STEADY-PD III is a multicenter NINDS funded…A healthy volunteer phase 1 study of RE-024, a potential phosphopantothenate replacement therapy for patients with pantothenate kinase-associated neurodegeneration (PKAN)
Objective: To assess the safety, tolerability, and pharmacokinetics of single oral doses of RE-024 in healthy adult volunteers. Background: PKAN is a rare, autosomal recessive,…Distribution of oscillatory activities in MRI confirmed subthalamic nucleus subregions
Objective: To explore the differences and similarities of oscillatory activity between subregions of the subthalamic nucleus (STN). Background: In Parkinson's disease (PD), treatment driven changes…Upregulated vascular endothelial nitric oxide synthase in Parkinson’s disease cases that have received subthalamic stimulation: A post-mortem evaluation
Objective: Here we measured levels of vascular endothelial nitric oxide synthase (eNOS) expression as a result of high frequency (HF) Deep Brain Stimulation (DBS) of…Strengths and weaknesses of patient-reported outcomes following DBS surgery: Comparing clinician, patient, and caregiver assessments
Objective: Assess the degree of correlation between DBS outcome measures rated by patients, caregivers, and clinicians. Methods: The Clinician Global Impression (CGI) score and two…The long-term follow-up of subthalamic nucleus deep brain stimulation comparing medication alone in advanced Parkinson’s disease patients
Objective: To investigate whether advanced Parkinson's disease (PD) patients receive subthalamic nucleus deep brain stimulation (STN-DBS) or medical treatment alone have different long-term outcome. Background:…Pisa syndrome in Parkinson’s disease effectively treated with subthalmic deep brain stimulation: Case report
Objective: To report the case of a 67-year-old Parkinsonian patient with significant and disabling Pisa syndrome (PS) successfully treated with subthalamic nucleus deep brain stimulation…Jaw opening dystonia and blepharospasm following bilateral VIM DBS for postural and action dystonic tremor
Objective: We report an elderly patient with jaw opening dystonia and blepharospasm post-bilateral thalamic DBS performed for atypical dystonic tremor. Background: Ventral intermediate nucleus (VIM)…Constant-current stimulation in Parkinson’s disease patients
Objective: To evaluate the clinical effect (motor, non-motor and cognitive) of a three-month switch from constant-voltage (CV) to constant-current (CC) stimulation in Parkinson's disease (PD)…Employing intraoperative microelectrode recordings during "asleep" deep brain stimulation surgery of the globus pallidus internus in Parkinson’s disease
Objective: To employ a means of implanting DBS leads to the GPi in individuals with Parkinson's disease who are undergoing the surgery under general anesthesia…
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