Analysis of relationships between spinal deformity and walking ability in Parkinson’s disease patients
Objective: To determine the impact on walking ability of spinal deformity and imbalance as distinct from movement disorder in Parkinson's disease (PD). Background: Despite a…Selenotranscriptomic analyses identify signature selenoproteins in brain regions in a mouse model of Parkinson’s disease
Objective: In this study, we investigated the selenotranscriptome (24 selenoproteins in total) in five brain regions (cerebellum, substantia nigra, cortex, pons and hippocampus) in a…Dysregulated macroautophagy and mitochondrial dynamics in PD with glucocerebrosidase mutations
Objective: To investigate markers of macroautophagy and mitochondrial dynamics in fibroblasts and postmortem brain of Parkinson's disease (PD) patients with glucoerebrosidase (GBA1) mutations and controls.…Bcr-Abl tyrosine-kinase inhibitors (B-ATKI) and Parkinson’s disease (PD)
Objective: Looking through the Kaiser Permanente National Parkinson's disease Registry, generated through the electronic medical records (EMR), we took a first step in looking at…Reach-to-grasp impairments of both hands in individuals with Parkinson’s disease
Objective: To compare the reach-to-grasp (RTG) planning, kinematics and coordination of the less- (left) and more affected (right) hand in Individuals with Parkinson's disease (PD)…Micro-RNA in cerebrospinal fluid as a biomarker for early diagnosis, differential diagnosis and prognostic marker in Parkinson’s disease
Objective: This study aims to identify specific micro-RNA (miRNA) patterns in cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and to compare them with…Histone deacetylase 4 is regulated by microRNA 128 in SH-SY5Y cells of Parkinson’s disease
Objective: To explore the mechanisms and regulating effects of microRNA 128 in Parkinson's disease (PD). Background: PD is the second common progressive neurodegenerative disorder characterized…Exploring aging-VMAT2 gene-rotenone interactions in a cell model for Parkinson’s disease
Objective: To develop a Parkinson's disease (PD) model based on aging, vesicular monoamine transporter 2 (VMAT2) gene susceptibility and chronic rotenone exposure in SK-N-SH cell,…Falls in Parkinson’s disease: Beware the short, slow steps
Objective: To determine if step length influence falls in Parkinson's disease (PD) patients. Background: Falls are major cause of disability in PD. The objective of…Altered glutamate response and calcium dynamics in iPSC derived striatal neurons from XDP-patients
Objective: Our objective was to generate an in vitro model of XDP based on striatal neurons differentiated from induced pluripotent stem cells (iPSC), followed by…
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