Development of a prototype alpha-synuclein vaccine to induce T regulatory cells for the treatment of synucleonopathy
Objective: Test the hypothesis that combining humoral and immunosuppressive cellular asyn immunization will enhance asyn clearance, and reduce inflammation and neuropathological symptoms in a human…Dopamine replacement medication improves acquisition, retention, and transfer of skilled upper extremity movement in people with Parkinson Disease.
Objective: To determine whether i) dopamine replacement medication affects learning of an upper limb (UL) feeding task in people with Parkinson disease (PD), and ii) training…Diphasic Dyskinesias during levodopa-carbidopa intestinal gel (LCIG) infusion: diagnosis and management in clinical practice.
Objective: To describe the occurrence, diagnostic approach, clinical management and outcome of diphasic dyskinesias (Dyskinesias-Improvement-Dyskinesias, DID) in a large group of Parkinson’s Disaese (PD) patients…AAV-mediated over-expression of VEGF-B in PINK1 gene knockout rats increases striatal dopamine content
Objective: To evaluate overexpression of the neuroprotective vascular endothelial growth factor B (VEGF-B) in a genetic Parkinson’s disease (PD) model. Background: We have shown in…Topography of essential tremor
Objective: To explore the prevalence and clinical correlates of head and/or voice tremor in essential tremor. Background: Topography of tremor manifestations is poorly investigated in…A Service Evaluation of the Clinical Use of Parkinson’s KinetiGraph (PKG) Movement Recording System in the Assessment of Parkinson’s Disease Patients with Tremor
Objective: To evaluate the clinical usefulness of PKG Movement Recording System in the assessment process to aid recognition and understanding of tremor in patients with Parkinson’s disease…Comparison of the effect of thalamic DBS/coagulation on tremor and thalamic neuronal activity in spinocerebellar ataxia and essential tremor
Objective: To investigate the effects of deep brain stimulation (DBS) or lesions of the ventral intermediate nucleus (Vim) of the thalamus for spinocerebellar ataxia (SCA)…Living with Ataxia in Ireland 2016–a nationwide survey of 130 Irish patients with inherited Ataxia
Objective: To collect real-life data from a large cohort of patients with inherited ataxia in Ireland, with special attention to the individual ataxia-related healthcare resources…Indian ARSACS (Autosomal Recessive Spastic Ataxia of Charlevoix- Saugenay): Clinical report of the first genetically proven case from India, due to a novel SACS duplication
Objective: Objective: To report clinical, imaging and genetic findings in a case of ARSACS from India Background: ARSACS was described initially from Quebec, Canada, and later…Psychiatric Manifestations of Neuroacanthocytosis Syndromes
Objective: We seek to describe the different clinical manifestations of neuroacanthocytosis syndromes and to focus especially on Psychiatric one. Background: The term “neuroacanthocytosis” is used…
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