SPG7-related ataxia in the Irish National Ataxia Clinic cohort: case series
Objective: To present comprehensive clinical, optical coherence tomography (OCT) and genetic findings on SPG7 –related cohort attending the National Ataxia Clinic in Ireland. Background: Hereditary…Progressive ataxia and palatal tremor: 2 autopsy cases of a novel tauopathy
Objective: We report clinical and neuropathological findings in 2 cases of sporadic progressive ataxia and palatal tremor (PAPT). Background: Sporadic PAPT is a rare syndrome characterized by mid-…[11C]PK11195 PET Imaging Reveals Neuroinflammation in Dementia with Lewy Bodies: NIMROD Study
Objective: To determine if subjects with dementia with Lewy bodies(DLB) have increased microglial activation in vivo compared to matched healthy controls as assessed using PET…Late-Onset Wilson’s disease, Dementia, Ekbom syndrome and whitte matter hyperintensities
Objective: The aim of this study is to describe a patient with late-onset Wilson’s disease, dementia and Ekbom Syndrome. Background: Wilson's disease is an autosomal-recessive disorder…Dynamics of brain iron content and cortical pencil lining in healthy aging: An MRI study
Objective: To characterize the dynamics of age-dependent iron accumulation in the brain with susceptibility-weighted imaging (SWI). Background: Neurodegeneration with brain iron accumulation (NBIA) is characterized…Volumetric analysis of limbic structures in patients with functional movement disorders
Objective: To evaluate amygdala and hippocampal volume in patients with functional movement disorders (FMD). Background: Functional neuroimaging studies in patients with FMD have demonstrated abnormalities…Basal Ganglia and Limbic Striatal Regions are Differentially Affected by Pramipexole: D3 receptor – Mediated Changes in Markers of Synaptic Strength
Objective: To determine whether pramipexole (PPX) differentially upregulates AMPA receptor trafficking in limbic vs. motor striatal regions of rats. Background: Impulse control disorders (ICD) are…Is there a significant relationship between weight loss and prevalence of side effects of Parkinsonian medication? A retrospective, single-centre analysis, South Wales, UK.
Objective: To investigate if there is a significant relationship between weight loss in persons with Parkinson’s disease and side-effect incidence, and if so to what…The association between motor laterality and cognitive impairment in Parkinson’s disease
Objective: Our study aimed to compare the cognitive function depending on the one-sided symptom dominance for investigating association between specific cognitive function and asymmetric motor…Multimodal biomarkers as predictors of cognitive decline in Parkinson’s Disease
Objective: To identify a set of multimodal biomarkers to predict cognitive decline in non-demented Parkinson’s disease patients. Background: People with Parkinson’s Disease are at high…
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