Effectiveness of Deep Brain Stimulation (DBS) in Mice with Spinocerebellar Ataxia (SCA1).
Objective: To evaluate the effectiveness of Deep Brain Stimulation (DBS) in a mouse model of Spinocerebellar Ataxia type 1 (SCA1). Background: Spinocerebellar ataxia type 1…Delayed progressive spastic cerebellar ataxia and cerebellar atrophy after Heat Stroke
Objective: To describe a very rare case of delayed progressive spastic cerebellar ataxia after an episode of survival after heat stroke Background: Heat stroke is…Non-Progressive Coreoatethosis Secondary to Infantile Necrotizing Encephalopathy Mimicking Leigh Disease.
Objective: Our objective is to report image findings of an acute necrotizing encephalopathy of childhood (ANEC) in a 15 years-old girl, completely normal until 18…Using eye tracking to identify pupil and saccade biomarkers of neurodegenerative disease
Objective: The Ontario Neurodegeneration Research Initiative Program (1) is investigating patients with neurodegeneration (Alzheimer’s disease: AD; mild cognitive impairment: MCI; Parkinson’s disease: PD; amyotrophic lateral…Reappraisal of Progressive Myoclonus Ataxia
Objective: To define the clinical, electrophysiological and etiological features of progressive myoclonus ataxia (PMA). Background: PMA, formerly known as the Ramsay Hunt syndrome, is a…PBB3 Imaging in Parkinsonian disorders: evidence for binding to abnormally aggregated proteins in addition to tau proteins
Objective: To study selective regional binding for tau pathology in vivo, using PET with [11C]PBB3 ([11C]methylamino pyridin-3-yl buta-1,3-dienyl benzo[d]thiazol-6-ol) in tauopathies, and in conditions not…Using cognitive computing to identify compounds with antidyskinetic potential for Parkinson’s disease
Objective: IBM Watson for Drug Discovery (WDD) is a platform that analyzes vast quantities of scientific data to help researchers identify hidden connections and formulate…Rotenone induces astrocyte-mediated non-cell autonomous dopaminergic neurotoxicity
Objective: In this study, we examined involvement of astrocytes in rotenone-induced dopaminergic neurotoxicity using primary cultured cells. Background: Several studies reported that pesticide exposure, such…Tau predicts cognitive impairment in a prospective longitudinal CSF study in Parkinson’s Disease
Objective: We hypothesize that CSF profiles of Aβ and Tau (total and phosphorylated) are associated with clinical subtypes and disease progression. Background: Parkinson’s disease (PD)…The Cats & Dogs Test: a web-based platform to detect early visual processing deficits in Parkinson’s disease
Objective: To develop a sensitive web-based test to detect visuo-perceptual deficits in patients with Parkinson’s disease as an early marker of dementia. Background: Up to…
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