Metabolomic biomarkers strongly differentiate PD from healthy controls (HCs) in BioFIND study* specimens
Objective: To determine if metabolomic analysis - untargeted profiling of small-molecule (<1.5 kDalton) biochemical constituents - can yield useful diagnostic biomarkers of PD using CSF…Metabolic syndrome: Its link with motor function of Parkinson’s disease (PD)
Objective: To evaluate if metabolic risk factors can affect the motor function of PD patients Background: The etiology of PD remains unclear. It has been…Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition
Objective: In this study, we investigated the role of autophagy system in MANF-mediated neuroprotection against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Background: Autophagy and apoptosis are commonly involved…Relationship between the presence of colonic a-synuclein and MDS research criteria for prodromal PD in patients without manifest motor parkinsonism (PARCAS study)
Objective: The aim of the study was to assess the prevalence of prodromal PD based on the MDS research criteria in a population of patients…Association of CSF biomarkers with motor and non-motor features in moderately advanced Parkinson’s disease cohort: the BioFIND study
Objective: Evaluate associations between CSF biomarkers of neurodegeneration and clinical phenotype in Parkinson’s disease (PD) participants of the BioFIND cohort. Background: Levels of CSF α-synuclein…Dural lymphatic vasculature in human superior saggital sinus: the brain drain
Objective: To provide independent validation in human dura obtained at autopsy of the reported presence of dural lymphatic vessels. Background: Two recent studies have challenged…Deep Brain Stimulation (DBS) battery longevity of Medtronic Activa SC is briefer than preceding Soletra models, a within subject analysis
Objective: To contrast the durations of Activa SCs with the durations of preceding Soletra neurostimulator models within the same individuals programmed at near constant parameters.…Development of a Paroxysmal Movement Disorder Diary for Patients with Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)
Objective: To perform qualitative research to develop and establish content validity of a new clinical outcome assessment (COA) instrument for paroxysmal movement disorders in Glut1…Spg 11 gene mutation associated autosomal recessive hereditary spastic paraplegia presenting with partially levodopa responsive parkinsonism, stereotypy and cognitive decline.
Objective: To describe a rare case of SPG11 gene mutation associated complex hereditary spastic paraplegia with partially levodopa responsive parkinsonism Background: Hereditary Spastic Paraplegia (HSP)…The AppTUG : a new application for analyzing the Timed Up and Go task in patients with neurological disorders
Objective: To perform an initial validation of a newly developed smartphone-based Timed Up & Go (TUG) application (AppTUG), by comparing its measurements to the stopwatch-measured…
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