Non-invasive, automated corneal nerve quantification reveals neurodegeneration in Parkinson’s disease: A potential novel imaging biomarker
Objective: The aim of the study is to use automated analysis of corneal confocal microscopy (CCM) images to allow rapid and reliable quantification of corneal…Identifying the neural correlates of doorway freezing in Parkinson’s disease
Objective: We aimed to combine a previously validated virtual reality gait paradigm with functional Magnetic Resonance Imaging (fMRI) to investigate the neural correlates underlying doorway-provoked…Characteristics of brain mri in patient with Parkinson’s disease
Objective: To investigate the characteristics and brain MRI findings in patient with Parkinson’s Disease Background: Parkinson's Disease is a chronic, progressive neurodegenerative disease that is…Effects of subthalamic nucleus deep brain stimulation in Parkinson’s disease are mediated by a prefronto-cerebellar-striatal loop
Objective: To determine DBS-related changes of a motor network using resting state fMRI in PD patients with chronic STN-DBS. Background: In Parkinson’s disease (PD), dopamine…A cortical neural signature of motor interruption in patients with Parkinson’s disease and freezing of gait
Objective: To investigate whether cortical oscillations involved in sensorimotor and perceptual processes [alpha (8-12 Hz), low beta (13-20 Hz) and high beta (21-35 Hz)] change…Microstructural Changes in Normal Appearing White Matter in Parkinson’s Disease (PD) Correlate with Motor, Tremor, and Neuropsychiatric Scores
Objective: To determine if microstructural changes in the normal appearing white matter of PD are associated with clinical manifestations of disease. Background: White matter (WM)…Subthalamic Nucleus Local Field Potential Beta Activity in Chinese Advanced PD Patients
Objective: To test if the β oscillations of subthalamic nucleus (STN) local field potential (LFP) in Chinese advanced Parkinson’s disease (PD) patients are similar with…Temporal evolution of biomarkers from healthy ageing, isolated REM sleep behavior to early Parkinson’s disease
Objective: To study the temporal evolution of biomarkers of various modalities in healthy ageing controls (HC), the prodromal condition of isolated REM sleep behavior disorder…α-synuclein propagation via olfactory pathway in non-human primate model
Objective: Recent studies have revealed that intracerebral injection of synthetic α-synuclein (α-syn) fibrils into olfactory bulb (OB) of mice induced prion-like propagation of α-syn aggregates…Subthalamic nucleus stimulation normalises effort-based decision-making in Parkinson’s disease
Objective: To compare the influence of levodopa and subthalamic nucleus stimulation (STN-DBS) on effort-based decision-making in Parkinson’s disease (PD). Background: Idiopathic PD is a neurodegenerative…
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