Clinical differences between Parkinson’s disease motor phenotypes. Results from the COPPADIS Study Cohort
Objective: To describe the prevalence of different motor phenotypes in a large cohort of Parkinson´s disease (PD) patients and to analyze their clinical features in…Preliminary Study of Depression in Parkinson’s Disease with Diffusion Tensor Imaging
Objective: To explore the relationship between cognitive impairment in Parkinson’s Disease(PD) and the microstructure changes of brain region of interest(ROI) in diffusion tensor imaging(DTI). Background:…Impact of injection guidance techniques on the efficacy and safety of incobotulinumtoxinA for sialorrhea
Objective: SIAXI (NCT02091739), a pivotal double-blind, randomised, placebo-controlled study with an extension period (EP), assessed the efficacy and safety of incobotulinumtoxinA 75 or 100 U…Validation of a patient/caregiver questionnaire to evaluate nocturnal hypokinesia in Parkinson’s disease
Objective: To develop and validate a novel questionnaire to assess various aspects related to problems experienced by PD patients when turning in or getting out…Bidirectional gut-to-brain and brain-to-gut propagation of α-synuclein pathology in non-human primates
Objective: The prototypic synucleinopathy Parkinson's disease (PD) is hypothesized to spread out from the enteric nervous system (i.e. the gut) via the vagal nerve up…Unveiling the function of altered gut microbiota composition in Parkinson’s disease
Objective: To investigate the gut microbiome and metabolome in Parkinson’s disease (PD). Background: Recent evidence revealed that gut microbes promote alpha-synuclein pathology and motor deficits…Salivary Alpha-Synuclein a new tool for the diagnosis of Parkinson’s disease?
Objective: The aim of the PARKSYN study was to test the utility of salivary alpha-synuclein (a-syn) concentration in the differential diagnosis between Parkinson's disease (PD)…Serum Leptin levels in Iranian patients with Parkinson’s disease
Objective: Parkinson’s disease (PD) is the second most common neurodegenerative disorder that frequently affects elderly population worldwide. Initially, PD was known as a motor disorder…Effects of Glial Heme Oxygenase-1 on Neuronal Alpha-Synuclein in the GFAP.HMOX1 Mouse Model of Parkinson’s Disease
Objective: To determine whether astroglial HO-1 transduces environmental and endogenous stressors into patterns of neural damage which promote the toxicity of neuronal alpha-synuclein. Background: The…Classification of Dopaminergic-State and Motor Activity by Theta, Beta and Gamma Activity in Parkinson’s Disease
Objective: To test whether machine learning algorithms are suitable to classify dopamine and behavioral states in Parkinson’s patients (PD). Background: While motor symptoms of PD…
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