Activation of chaperone-mediated autophagy reduces oligomeric alpha-synuclein accumulation in LRRK2(R1441G) knockin mouse model of Parkinson’s disease (PD)
Objective: To determine age-dependent accumulation of oligomeric alpha-synuclein in the brain of aged LRRK2(R1441G) knockin mice; and to explore whether activation of chaperone-mediated autophagy (CMA)…Prefrontal cortical stimulation to treat anxiety and depression in Parkinson’s disease
Objective: The aims of this study are 1) to study the neurophysiology underlying anxiety and depression in PD patients, and 2) to determine whether cortical…Direction of Turning in Parkinson’s Disease: More Affected Side or Less Affected Side?
Objective: The aim of this study is to investigate differences of gait characteristics according to direction of turning more and less affected side (MAS and…Neuropathological correlates of psychiatric disorders in PD
Objective: To test the hypothesis that neuropsychiatric symptoms (NPS) in PD are associated with histopathologically confirmed neuronal loss and gliosis (NLG) in the locus coeruleus…Impulsive-Compulsive Behaviour disorders: A longitudinal study in de-novo in Parkinson’s disease patients
Objective: To investigate whether early development of impulsive-compulsive behaviours (ICB) in de novo Parkinson’s disease (PD) is associated to a different clinical progression of motor…Patterns of Long-Term Custodial Care in Parkinson Disease Psychosis
Objective: Parkinson Disease (PD) progression is frequently associated with development of psychosis (P), leading to significant morbidity, caregiver distress, and other consequences. Although PDP often…The Reliability Study of King’s Parkinson’s Disease Pain Scale in Indonesian Version
Objective: To create the reliable Indonesian Version of King’s Parkinson’s Disease Pain Scale. Background: Pain is one of the most common non-motor symptoms of Parkinson’s…Low-Fat Versus Ketogenic Diet In Parkinson’s Disease: A Pilot Randomized Controlled Trial
Objective: To compare the plausibility, safety, and efficacy of a low-fat, high-carbohydrate diet versus a ketogenic diet in a hospital clinic of PD patients. Background:…A Phase 2 Efficacy Study of CX-8998, a Potent and Selective T-Type Calcium (Cav3) Modulator in Parkinson’s disease Tremor (PDT) Patients: Design and Dose-Selection Rationale
Objective: The objective of this study is to access the efficacy of CX-8998 using the MDS-UPDRS Tremor Score (MDS-UPDRS-TS) and a digital biomarker platform, while…Motor and non-motor correlates of APOE-ε4 mediated cerebrospinal fluid concentrations of amino acids and monoamine metabolites in dementia with Lewy bodies compared with Alzheimer’s dementia and healthy controls
Objective: To study associations of cerebrospinal fluid (CSF) amino acids and monoamine metabolites with motor and non-motor features in dementia with Lewy bodies (DLB) compared…
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