Putaminal dopamine depletion in de novo Parkinson’s disease predicts future development of wearing-off
Objective: The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson’s disease.…Optimization of deep brain stimulation in STN among patients with Parkinson’s disease using a novel EEG-based tool
Objective: The current study aims to develop an innovative method for objective differentiation between the locations of the four DBS contacts in the various parts…Behavior and PET Imaging Study in Parkinsonian Rat Models Induced by Injection of 6-OHDA in Medial Forebrain Bundle
Objective: To employ behavioral test, positron emission tomography (PET) imaging and immunohistochemical staining to assess the changes of brain function and dopaminergic system in rat…Motor cortical inhibitory and facilitatory circuit interactions in Parkinson’s disease
Objective: To determine how intracortical circuits interact with one another in Parkinson’s disease. Background: Using transcranial magnetic stimulation (TMS), previous work has established that motor…The difference in cerebellar blood flow reduction in multiple system atrophy and Parkinson’s disease
Objective: The aim of this study is to determine if cerebral blood flow (CBF) reduction in the cerebellum could be a tool for differential diagnosis…Return to automaticity: cortical activity during gait in Parkinson’s disease
Objective: This study investigated pre-frontal cortex (PFC) activation while walking in older adults and people with Parkinson’s disease (PD). We specifically examined 1) PFC activation…Neuroprotective effect of exogenous melatonin on apoptosis of neuroadernergic neurons in a rat model of Parkinson’s disease
Objective: To investigate melatonin therapeutic potential effects in Parkinson’s disease. Background: Sleep disorders constitute major nonmotor features of Parkinson’s disease (PD) that have a substantial…Characterization of the gastrointestinal dysfunction in mice overexpressing the human mutation (A53T) of alpha-synuclein
Objective: The aim of this study was to determine if mice overexpressing the human mutation of alpha-synuclein develop gastrointestinal (GI) dysfunction, and to understand the…Clinical subtypes of Parkinson’s disease based on nonmotor symptoms: A cluster analysis
Objective: To classify patients with early Parkinson's disease based on nonmotor symptoms using a data-driven approach. Background: Heterogeneity of Parkinson’s disease provides the basis for…Improvement of Levodopa-Responsive Chronic Pain after STN-DBS in Parkinson’s disease
Objective: To illustrate an example of an improvement in chronic pain, following bilateral subthalamic nuclei (STN) deep brain stimulation (DBS) surgery in a Parkinson’s disease…
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