Botulinum toxin content and activity: Potential implications for duration of efficacy in patients with cervical dystonia
Objective: To quantify the amount of botulinum neurotoxin-A (BoNT-A) protein in each vial of commercial BoNT-A product and compare light chain activity of 150 kDa…Long-term treatment of cervical dystonia with abobotulinumtoxinA
Objective: To evaluate long-term efficacy and safety of the treatment of cervical dystonia (CD) with abobotulinumtoxinA in daily life routine in an outpatient clinic for…Combined Botulinum Toxin and Gpi DBS therapy in intractable cervical dystonia
Objective: To test whether the reintroduction of Botulinum Toxin Injections (BTI) after Globus pallidus interna Deep Brain Stimulation (Gpi-DBS) for intractable cervical dystonia synergistically improves…Trust the Patient’s Report, not the Doctor’s: Non-Motor Symptoms and Quality of Life in Cervical Dystonia
Objective: To assess the prevalence of mood disorder and measure health-related quality of life (Hr-QoL) in relation to, pain, disability and disease severity in cervical…Pregnancy and Delivery Complications in Women with Inherited Isolated Dystonia
Objective: To determine whether female mutation carriers of inherited dopa-responsive (DRD) and DYT/TOR1A genes had higher pregnancy and delivery complications than non-carriers Background: Women with…PRRT2 mutations are associated with a wide intrafamilial ad interfamilial phenotypic variability
Objective: To describe the different clinical syndromes associated with PRRT2 mutations in two different families Background: Mutations in the Proline-Rich Transmembrane Protein 2 (PRRT2) gene…Guided Self-rehabilitation Contracts combined with simultaneous injections of abobotulinumtoxinA into upper and lower limbs in spastic hemiparesis: baseline data from the ENGAGE study
Objective: To report baseline data from ENGAGE, an international phase 3b/4, prospective, single-arm, open-label study (NCT02969356) conducted in France, the Czech Republic, Russia and the USA.…Algorithm of a differentiated approach to the management of patients with tic hyperkinesis
Objective: Develop an algorithm for diagnosis and differentiated approach to the management of patients with tics Background: The prevalence of tics reaches 20%; often accompanied…Is directional stimulation of the VIM superior to omnidirectional stimulation in patients with essential tremor?
Objective: To determine whether directional stimulation of the VIM is superior to omnidirectional stimulation in essential tremor. Background: Deep brain stimulation (DBS) of the VIM…Searching for the optimal functional target for deep brain stimulation in Essential Tremor
Objective: To investigate tremor improvement but also side effects of deep brain stimulation (DBS) for essential tremor (ET) and their relationship to the volumes of…
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