Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: In this report, initial real-world outcomes using a directional lead with a Deep Brain Stimulation (DBS) system capable of multiple independent current source control (MICC) for use in managing symptoms of levodopa-responsive Parkinson’s disease (PD) will be reported.
Background: Deep Brain Stimulation (DBS) systems have historically used ring-shaped electrodes that produce stimulation fields with limited control over field shape and volume of tissue activated. Directional current steering may permit a more personalized DBS approach with respect to individualized shape and pattern of electrical field and corresponding volume of tissue activated.
Method: The Vercise DBS Registry (ClinicalTrials.gov Identifier: NCT02071134) is a prospective, on-label, multi-center, international registry sponsored by Boston Scientific. Subjects in this cohort were implanted with a directional lead included as part of a multiple-source, constant-current directional DBS system (Vercise Cartesia, Boston Scientific). Subjects were followed up to 3-years where their overall improvement in quality of life and PD motor symptoms was evaluated. Adverse events were collected.
Results: To date, 200 enrolled patients have been implanted with the directional lead. Improvement in Quality of Life following DBS implant with the directional lead was demonstrated at 6 months and 1-year post implant.Improvements in motor function (change in MDS-UPDRS III scores – meds off condition) was also noted.Additional data is to be presented.
Conclusion: Enabling fractionalization of current using MICC can permit application of a well-defined, shaped, electrical field.This on-going registry represents the first comprehensive, large scale collection of real-world outcomes using a directional lead and an MICC-based DBS system.
To cite this abstract in AMA style:J. Vesper, R. Jain, A. Wang, H. Scholtes, V. Study Group, G. Deuschl. Real World Clinical Outcomes Using a Novel Directional Lead from a Multicenter Registry of Deep Brain Stimulation for Parkinson’s Disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/real-world-clinical-outcomes-using-a-novel-directional-lead-from-a-multicenter-registry-of-deep-brain-stimulation-for-parkinsons-disease/. Accessed December 10, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/real-world-clinical-outcomes-using-a-novel-directional-lead-from-a-multicenter-registry-of-deep-brain-stimulation-for-parkinsons-disease/