Public awareness and education of Parkinson’s Disease among Nepalese Population
Objective: This study aimed to evaluate the knowledge of Parkinson’s Disease(PD) among general population and educate them with the clinical features of this disease for…The Clinical, Molecular and Radiographic Spectrum of Adaptor Protein Complex 4-associated Hereditary Spastic Paraplegia (AP-4-HSP): Results from the AP-4-HSP International Registry
Objective: 1) To develop a registry and natural history study for AP-4-HSP; 2) to define core clinical and radiographic features; 3) to explore genotype-phenotype correlations.…Daily variability of non-motor symptoms as a reflection of circadian dysregulation in Parkinson’s disease
Objective: To assess the daily variability of visual and autonomic nervous system (ANS) functions in relation to sleep disorders to determine circadian PD phenotypes Background:…Olfactory Hallucinations as a Non-motor sign of Parkinson’s disease- a cross sectional study
Objective: To describe the prevalence and characteristics of Olfactory Hallucinations (OlfH) in patients with Parkinson’s Disease (PD) in a tertiary movement clinic. Background: Hallucinations are…Circadian and Homeostatic Modulation of Multi-unit Activity in Dopaminergic and Striatal Structures
Objective: This study aims at investigating the impact of sleep and sleep deprivation on neuronal activity of midbrain dopaminergic areas and different subdivisions of the…Nonmotor Symptoms in Parkinson’s Disease: 36-month Follow-up Study Comparing Bilateral Subthalamic Stimulation and Standard-of-care Medication
Objective: To examine 36-month effects of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on nonmotor symptoms (NMS) and self-reported quality of life compared to…The Urge to Move in Restless Legs Syndrome Associated with Parkinson’s Disease: A Motor Impulse Control Disorder?
Objective: To determine whether there could be a semiological overlap between Restless Legs Syndrome (RLS) and Impulse Control Disorders (ICDs) in Parkinson’s Disease (PD), using…Phosphodiesterase 10A and cognition in Parkinson’s disease
Objective: We aimed to assess the associations between Phosphodiesterase 10A (PDE10A) expression in the executive striatum and cognitive performance in vivo, using [11C]IMA107 PET and…Occurrence of brain capillary dysfunction in patients with REM sleep behavior disorder
Objective: To assess whether changes in brain capillary function measured with magnetic resonance imaging (MRI) can be detected in patients with REM sleep behavior disorder…No link between striatal dopaminergic axons and dopamine transporter imaging in Parkinson’s disease
Objective: The objective of this study was to investigate if dopamine transporter (DAT) binding is associated with dopaminergic neurites in the putamen. Background: Dopamine transporter…
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