Neuroanatomical and clinical predictors of pain in patients with early de novo Parkinson’s disease
Objective: We investigated associations between clinical features, neuroanatomical changes and pain in early de novo Parkinson’s disease (PD) patients. Background: Pain is a common and…Serum uric acid levels and cognitive function in Parkinson’s disease
Objective: To compare serum uric acid (sUA) levels in Parkinson’s disease (PD) subjects to cognitive function. Background: Reduced sUA levels have been reported in individuals…Deep Brain Stimulation as second line advanced treatment for PD after LCIG
Objective: Staging of advanced treatments for Parkinson's disease such as levodopa–carbidopa intestinal gel infusion (LCIG) and Deep brain stimulation (DBS) Background: Device-aided therapies for Parkinson’s…Bilateral vestibulopathy due to neurosarcoidosis mimicking Parkinsonian syndrome
Objective: We here describe a patient with neurosarcoidosis presenting with progressive gait disturbance that mimics Parkinsonian syndrome. Background: Neurosarcoidosis can show various neurological complications; however,…Towards unobtrusive Parkinson’s disease detection via motor symptoms severity inference from multimodal smartphone-sensor data
Objective: To provide clinically-corroborated evidence of the Parkinson’s disease (PD) diagnostic potential of machine learning-based approaches for motor symptoms severity inference via multimodal data, passively…Premature State of Oligodendrocytes Potentially Provides Critical Period for Extracellular Pathological α-Synuclein to Invade Oligodendrocyte Lineage Cells
Objective: Multiple system atrophy (MSA) is pathologically characterized by accumulation of misfolded α-synuclein (α-syn) in oligodendrocytes (OLGs), which is known as glial cytoplasmic inclusions (GCIs).…Gaze – evoked nystagmus in PSP patients: Is it really atiypical? A case series of eight patients
Objective: To present eight patients with progressive supranuclear palsy (PSP) syndrome and horizontal, gaze-evoked nystagmus (GEN), a finding hitherto assumed atypical for PSP[1]. Background: The…Cognitive dysfunction in patients with Parkinson’s disease and psychosis
Objective: The objective of this study was to explore the pattern of cognitive dysfunction in the patient's with Parkinson's disease and psychosis (PD-P) by comparing…The effects of obstacle size and timing on prefrontal cortex activation in patients with Parkinson’s disease
Objective: To evaluate the effects of obstacle height and anticipation time on prefrontal cortex (PFC) activation in patients with Parkinson's disease (PD) and older adults.…Memantine and 3D gait analysis in patient with Parkinson’s disease: an observer-blind randomized clinical trial
Objective: To examine the efficacy of memantine (20 mg), a non-competitive NMDAR antagonist, in the treatment of gait impairment in PD patients with mild cognitive…
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