Effect of opicapone and entacapone on early morning-OFF pattern in Parkinson’s disease patients with motor fluctuations
Objective: To evaluate the effect of opicapone (OPC) 50 mg versus entacapone (ENT) on early morning-OFF (EMO) pattern. Background: OPC, a once-daily catechol-O-methyltransferase inhibitor, was…CHCHD2 mRNA levels in erythrocyte are reduced in patients with multiple system atrophy
Objective: To investigate CHCHD2 mRNA expression of erythrocyte in patients with multiple system atrophy (MSA). Background: Coiled-coil-helix-coiledcoil-helix domain containing 2 (CHCHD2) are reported to be associate with…Clinical features and natural course of corticobasal degeneration and progressive supranuclear palsy presenting as corticobasal syndrome
Objective: To compare clinical features and natural course of corticobasal degeneration (CBD) presenting as corticobasal syndrome (CBD-CBS) and progressive supranuclear palsy presenting as corticobasal syndrome…The Progressive Supranuclear Palsy Clinical Deficits Scale
Objective: To develop a scale to monitor clinical deficits in patients with Progressive Supranuclear Palsy across its broad phenotypes. Background: There is currently no undisputed,…Atypical parkinsonism due to a mutation in the SLC9A6 gene
Objective: Expanding phenotypic spectrum in christianson syndrome (CS). Background: CS is an X-linked neurodevelopmental disorder characterized by intellectual disability combined with microcephaly, cognitive impairment, ataxia,…Multi-level and multi-pattern lower- and upper-limb spasticity treatment with incobotulinumtoxinA in children and adolescents with cerebral palsy
Objective: Assess efficacy and safety of incobotulinumtoxinA in lower-limb (LL) or combined LL/upper-limb (LL/UL) spasticity in children and adolescents with cerebral palsy (CP). Background: Ambulant…Movement Disorders Analysis Using a Deep Learning Approach
Objective: Using a deep learning inspired approach, we developed a tool to compute an objective score of bradykinesia. Background: Bradykinesia is defined as a motor…SLC20A2 mutation manifesting as very-late onset orofacial dyskinesia
Objective: We report two cases of genetically confirmed PFBC with a SLC20A2 mutation that presented with very-late onset orofacial dyskinesia. Background: Primary familial brain calcification…A Virtual Speech Therapist for Parkinson’s Disease
Objective: This study was designed as a pilot investigation to explore the use of virtual therapy in the delivery of LSVT LOUD ® (Lee Silverman…Preferences for exercise in people with Parkinson’s disease: A discrete choice experiment
Objective: To identify attributes of evidence-based exercise programs associated with the willingness of people with Parkinson’s disease (PD) to engage in additional exercise. Background: People…
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