Pilot study of Phenotype of Antisense-Oligonucleotide-(ASO)-knockdown of Cerebral-Dopamine-Neurotrophic-Factor (CDNF) as Parkinson Disease model : implications for PD and related Dementia Therapeutics
Objective: Our objective is twofold: 1)to examine whether CDNF-ASO paradigm can induce a unique phenotype mimicking PD/PDD/LBW in the rodent species; 2) to evaluate whether…Attitudes on therapy-associated risks in individuals with multiple system atrophy and Parkinson’s disease and their views on aspects of clinical trials
Objective: To assess risk attitudes of patients suffering from multiple system atrophy (MSA) and Parkinson’s disease (PD) on future disease-modifying therapies as well as related…Progression of nigro-striatal denervation in cerebellar Multiple System Atrophy: a prospective study
Objective: To study the progression of nigro-striatal denervation and evaluate the capacity for [123I]-FP-CIT-SPECT and parkinsonian signs to differentiate MSA-C from idiopathic late-onset cerebellar ataxia…Quantitative downgaze palsy predicts the survival duration in patients with progressive supranuclear palsy
Objective: To study whether quantitative downgaze palsy could predict the survival duration in patients with progressive supranuclear palsy (PSP). Background: No clinical feature has been…Transcranial Magnetic Stimulation in Parkinsonism. Tremor and Biomechanics Evaluation
Objective: The aim of our study was to reveal the relationship between motor and muscle activity шт terms of plantar pressure distribution PPD) in Parkinson's…Post-Covid-19 Parkinson’s disease: a Brazilian case series.
Objective: To describe two patients with post-COVID-19 Parkinson’s disease (PD) and discuss their possible causes. Background: PD is a neurodegenerative disorder characterized by motor and…Spatiotemporal dynamics in mild cognitive impairment with Lewy bodies
Objective: To explore whether EEG microstate evaluation may help in identifying mild cognitive impairment with Lewy bodies (MCI-LB) and to assess whether the changes correlate…Sleep disorders and future diagnosis of parkinsonism: a prospective study using the Canadian Longitudinal Study on Aging
Objective: To determine whether symptoms of insomnia, somnolence, apnea, and restless legs syndrome predict the diagnosis of parkinsonism after three years of follow-up. Background: Earlier…NMDA Receptor Antibodies and Neuropsychiatric Symptoms in Parkinson’s Disease
Objective: To quantify the frequency of NMDA receptor (NMDAR) antibodies (Abs) in Parkinson’s disease (PD) and characterise their relationship with the cognitive and neuropsychiatric symptoms.…Comparisons Between Parkinson’s Disease Patients and At-Risk Individuals: Can Olfactory Deficits and Cognitive Measures Serve as Preclinical Markers?
Objective: To examine whether individuals at increased risk of developing Parkinson’s disease (PD) show specific cognitive impairments suggestive of progression towards PD. Background: Olfactory deficits…
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