Burden of illness among US Medicare beneficiaries with late-onset Huntington’s disease
Objective: Examine healthcare resource utilization (HRU) and costs among US Medicare beneficiaries with late-onset Huntington’s disease (LoHD). Background: Huntington’s disease (HD) is a genetic, neurodegenerative…The Burst Duration in Cortical Myoclonus Patients, What is the Cut-Off?
Objective: The aim of this study is to identify a cut-off value for the burst duration of cortical myoclonus in a large cohort of myoclonus…Efficacy of Incobotulinumtoxin/A Treatment for Children/Adolescents with Sialorrhea associated with Neurological Disorders
Objective: The SIPEXI (Sialorrhea Pediatric Xeomin Investigation) study investigated efficacy and safety of intraglandular incobotulinumtoxinA (incoBoNT/A) injections in children/adolescents with sialorrhea associated with neurological disorders…Stiff-person syndrome – a 15-year review at a tertiary hospital
Objective: Clinical characterization of stiff-person syndrome (SPS). Background: SPS typically presents with progressive symmetric axial and proximal limb rigidity, and episodic painful spasms triggered by…Spectrum of Movement Disorders among Children with Subacute Sclerosing Panencephalitis (SSPE): A Cross-sectional Study
Objective: We aimed to assess spectrum of movement disorders associated with pediatric SSPE. Background: Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder due to…Rapid Onset Stiff Person Syndrome
Objective: To present a case of rapid onset Stiff Person Syndrome (SPS) in a non-classic patient and review diagnostic considerations associated with his presentation. Background:…Challenges around end-of-life care for people with Parkinson’s disease in Kenya
Objective: To explore how people living with Parkinson’s disease (PwP), and their families, in Kenya negotiate the end of life. Background: Parkinson’s disease (PD) is…Impact of 3-month earlier versus postponed initiation of opicapone versus entacapone in levodopa-treated patients with Parkinson’s disease and motor fluctuations
Objective: This post-hoc analysis evaluated the impact of 3-month earlier versus postponed initiation of opicapone (OPC) in patients with Parkinson’s disease (PD) and motor fluctuations.…Study Design to Assess the Effect of Opicapone on Levodopa PK at Different Levodopa-Optimized Treatment Regimens in Parkinson’s Disease Patients
Objective: This study was designed to assess the effect of opicapone (OPC) 50 mg once daily (QD) on levodopa (L-DOPA) pharmacokinetics (PK) in different L-DOPA/carbidopa…Randomized, Placebo-Controlled Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of ABBV-0805, an Anti-Alpha-Synuclein Monoclonal Antibody in Healthy Subjects
Objective: To evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of ABBV-0805 following administration of single ascending doses of ABBV-0805, administered as intravenous (IV) infusions…
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