The role of amylin in Parkinson´s disease neurodegenerative process
Objective: We investigate the functional interaction between two amyloidogenic (amylin and synuclein) proteins as a potential mechanism for neurodegeneration in Parkinson disease (PD). Background: PD…Close relationship between CSF lipidomic alterations and cognitive decline in Parkinson’s disease.
Objective: To clarify what the lipidome of biological samples reflects in the pathology of Parkinson’s disease (PD). Background: The lipid pattern in the cerebrospinal fluid…Cortical microstructural alterations are more sensitive than morphology changes to cortical degeneration in Parkinson’s disease with mild cognitive impairment
Objective: To compare the sensitivity of detection cortical degenerative changes in patients with Parkinson’s disease (PD) and mild cognitive impairment (MCI) between the diffusion magnetic…An Eyes-Open/Closed Manipulation Reveals Disrupted Default Mode Network Connectivity in Parkinson’s Disease and REM Sleep Behavior Disorder
Objective: To spatially localize disruptions in default mode network connectivity in prodromal and diagnosed Parkinson’s disease relative to controls. Background: Previously our research team reported…Tractography Analysis of the Pedunculopontine Nucleus Correlates with Gait Impairment in Parkinson’s Disease
Objective: Our objective was to correlate pedunculopontine nucleus (PPN) connectivity with quantitative gait metrics in Parkinson’s disease (PD) using diffusion tensor imaging (DTI). Background: Gait…Relationship Between Hyposmia and Olfactory Network Connectivity in Patients With Parkinson’s Disease
Objective: To examine resting-state functional Magnetic Resonance Imaging in a group of Parkinson’s Disease patients, used to characterize changes in functional connectivity of the olfactory…Altered Resting-state Neural Activity in Parkinson’s Disease with Depression: a controlled study based on original meta-analysis results
Objective: Depression is a common non-motor symptom in Parkinson’s disease (PD), while its underlying pathophysiology remains unclear. Previous functional magnetic resonance imaging (fMRI) studies reported…Changes in the cerebellar activity during task based and resting state fMRI in Parkinson’s disease patients with mild cognitive impairment
Objective: To investigate possible brain markers for PD-MCI by undertaking cognitive task-based and resting-state fMRI. Background: Parkinson’s disease (PD) is widely recognised as a movement…The aperiodic component of cortical Local Field Potentials is affected in Parkinson’s Disease and Essential Tremor.
Objective: Characterize the pathophysiology of Parkinson’s Disease (PD) and Essential Tremor (ET) in terms of cortical and subcortical aperiodic neural activity. Background: Classical analysis of…Distinct oscillatory fingerprints in dyskinesias mediated by D1 versus D2 receptors
Objective: To characterize the patterns of cortico-basal ganglia oscillations induced by D1 or D2 receptor agonists in a rat model of L-DOPA-induced dyskinesia. Background: In…
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