Single-cell characterization of patient midbrain tissue reveals tissue remodeling and glial activation in Parkinson’s disease
Objective: We aim to characterize the contribution of each midbrain cell type to PD pathology, and to identify cell types associated with genetic PD-risk variants.…Sleep stability, arousals and cycle structure in alfa-synucleinopathies: a comparative study between isolated REM sleep behaviour disorder (iRBD), Parkinson’s Disease (PD) and Dementia with Lewy Bodies (DLB)
Objective: To compare sleep stability, arousals and sleep cycle structure between two sets of diagnosis: iRBD vs PD vs DLB; patients with RBD (RBD+) vs…Quality of life changes after subthalamic stimulation for Parkinson’s disease depend on nonmotor and motor symptoms clusters
Objective: To analyze quality of life (QoL) changes after subthalamic stimulation (STN-DBS) based on a short list of baseline nonmotor and motor symptoms in Parkinson’s…Emotion Recognition and Risk-Taking Behaviour in Early Parkinson’s Disease
Objective: To assess the association between facial emotion recognition and traffic-related risk-taking behaviour in early Parkinson’s Disease (PD) patients. Background: Risk-taking behaviour is an important…Challenges in Outcome Measure Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease
Objective: The Edmond J Safra Accelerating Clinical Trials in Parkinson Disease (PD) initiative (EJS ACT-PD) aims to accelerate the identification of disease modifying treatment for…Predictors of short-term anxiety outcome after subthalamic stimulation in Parkinson’s Disease
Objective: To identify clinical predictors of the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s Disease (PD). Background: STN-DBS is a…Assessment of cognitive functions and gait in PD and ET patients with pharmacoresistant tremor treated with Gamma Knife thalamotomy.
Objective: The aim of our study was to assess the impact of unilateral Gamma Knife thalamotomy on gait and balance and well as psychological functioning…BBP-671, AN INVESTIGATIONAL MODULATOR OF PANTOTHENATE KINASES, DEMONSTRATES PROOF OF CONCEPT IN A PKAN MOUSE MODEL AND TARGET ENGAGEMENT IN HUMANS
Objective: Efficacy of BBP-671 as a potential therapy for pantothenate kinase-associated neurodegeneration (PKAN) was evaluated in a PKAN mouse model. Safety, PK, and PD of…Targeted training improves touchscreen skills in Parkinson’s disease and healthy elderly
Objective: To investigate the effects of dual (DT) versus single task (ST) training of touchscreen skills in Parkinson’s disease patients (PD) and healthy elderly (HE).…Huntington’s Disease, Cognition, and Fear of Falling
Objective: Explore the relationship of cognition and patient-reported assessment on fear of falling in people with Huntington’s Disease. Background: Huntington’s Disease (HD) is a relentlessly…
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