Factors associated with progression of Parkinson’s disease and deterioration in quality of life: Results of J-FIRST, a 1-year observational study
Objective: To investigate whether individual non-motor symptoms (NMSs) are associated with overall NMS or quality of life (QOL) in Parkinson's disease (PD). Background: Worsening motor…Catatonic Syndrome in Covid-19 Infection: Medication Treatment or Hyperbaric Oxygen Therapy.
Objective: Catatonic syndrome, or catatonia (from other Greek κατατείνω - “stretch, strain”), is a psychopathological syndrome (a group of symptoms), the main clinical manifestation of…Prevalence and distribution of disease-associated alpha-synuclein in a homeless population
Objective: To study the prevalence and distribution of pathological alpha-synuclein deposition, throughout the central and peripheral nervous systems, in a homeless population. Background: The homeless…Vodobatinib, a potent, orally bioavailable brain-penetrating inhibitor of c-Abl as a potential neuroprotective agent for the treatment of Parkinson’s Disease
Objective: To compare and contrast nilotinib and vodobatinib regarding efficacy, brain penetration, and safety. Background: Preclinical evidence suggests that c-Abl is critical for pathogenesis of…Atypical parkinsonism presenting in late 60s in an individual with GCH1 mutation
Objective: To report a case of possible comorbid tau and Lewy pathology in an individual with a GCH1 mutation. Background: A 69-year-old man developed atypical parkinsonism…Occlusal Stabilization Appliance on treatment of cervical dystonia
Objective: To evaluate the effect of occlusal stabilization appliance on cervical dystonia. Background: Cervical dystonia is a contraction of the neck muscles that causes movement…Is motor symptoms asymmetry a possible predictor of short-term motor outcome of bilateral STN-DBS in Parkinson’s disease?
Objective: To evaluate if the body side of motor symptoms onset may predict the short-term motor outcome of bilateral subthalamic nucleus deep brain stimulation (STN-DBS)…Lower-limb dystonia as an explanation for freezing of gait responsive to cueing in Parkinson’s Disease
Objective: We aimed to search the literature for a potential association between freezing of gait (FOG) with cueing and dystonia with sensory tricks in Parkinson’s…Impaired behavioral proactive inhibitory control and flexibility in a mouse model of early Parkinson’s disease
Objective: The aim of our study is to address the impact of a moderate nigrostriatal DA lesion induced by 6-hydroxydopamine (6-OHDA) injection into the dorsomedial…The USP Project: Understanding the Scope and Value of Parkinson’s Specialist Nursing
Objective: This paper will present evidence from the first stakeholder-driven UK study to explore in-depth the role and value of the Parkinson’s Nurse Specialist (PNS)…
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