Expectations of DBS: the patient’s perspective
Objective: To examine the evolution and change of the treatment-related expectations of patients with advanced Parkinson’s Disease (PD) before and during treatment with bilateral deep…Quality of Life and Motor Outcomes for Parkinson’s Disease Patients 12 Months After Deep Brain Stimulation in China
Objective: Demonstrate improvement in Parkinson’s disease (PD)-related quality of life (QoL) for Deep Brain Stimulation (DBS) patients in a prospective, multicenter study conducted in China.…Unraveling the Potential of Specialized Allied Health Therapy in Parkinson’s Disease
Objective: To investigate discipline-specific effects of specialized Allied Health Therapy on the incidence of Parkinson’s Disease (PD)-related complications. Background: Specialized physiotherapy has been shown to…Effect of the mGlu2/3 orthosteric agonist LY-404,039 on dyskinesia, psychosis-like behaviours, and parkinsonism in the MPTP-lesioned marmoset
Objective: To assess the effect of LY-404,039 on dyskinesia, psychosis-like behaviours (PLBs) and parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset model of Parkinson’s disease (PD). Background:…Antidyskinetic Effects of CaV1.3 Calcium Channel Gene Silencing in Aged Male and Female Parkinsonian Macaques
Objective: To determine whether striatal CaV1.3 gene silencing ameliorates levodopa-induced dyskinesias (LID) in the preclinical gold-standard non-human primate (NHP) model without altering levodopa’s antiparkinsonian benefit.…Pilot case on the use of transcranial pulsed current stimulation(tPCS) in a patient with cervical dystonia(CD)
Objective: To demonstrate the efficacy of tPCS on a patient with CD Background: CD is a common adult-onset dystonia. Abnormal sensorimotor integration and maladaptive plasticity…Correlation between 3 Tesla Brain MRI Nigrosome-1 imaging and SPECT 123I-Ioflupane in parkinsonian disorders
Objective: To correlate nigrosome-1 (NG1) imaging and SPECT 123I-Ioflopane findings to determine the feasibility and diagnostic value of NG1 imaging in a real-world clinical setting.…Motor-Related and Cognition-Related Safety of Pimavanserin in Patients with Parkinson’s Disease Psychosis (PDP)
Objective: Evaluate motor- and cognition-related safety in pimavanserin-treated patients with PDP. Background: Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, is the only US FDA-approved treatment for…DIFFERENCE IN MOTOR AND NONMOTOR SYMPTOMS BETWEEN YOUNG AND LATE ONSET PARKINSON`S DISEASE
Objective: To evaluate difference in prevalence of nonmotor symptoms and severity of autonomic and motor symptoms between patients with young (YOPD) and late onset (LOPD)…Characterization of neuromelanin MRI as a potential Parkinson’s Disease biomarker in a multi-site longitudinal study
Objective: To investigate (1)longitudinal change and (2)cross-sectional vendor differences in neuromelanin MRI in substantia nigra pars compacta(SNpc) in PD patients. Background: Neuromelanin(NM) MRI is a…
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