Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study of Ecopipam in Children and Adolescents with Tourette Syndrome
Objective: Evaluate the efficacy and safety of ecopipam in children and adolescents with Tourette’s Syndrome (TS). Background: Ecopipam, a first-in-class selective dopamine-1 (D1) receptor antagonist…Development and validation of clinical scales for defining RBD severity in participants of the North American Prodromal Synucleinopathy (NAPS) consortium
Objective: The objective of this study is to assess the internal validity of the REM Sleep Behavior Disorder (RBD) symptom severity scale (RBDSSS) and its…Blood biomarkers and their association with non-motor symptoms in early Parkinson’s Disease
Objective: To identify if baseline blood biomarkers are associated with non-motor symptoms in early PD. Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with…Bilateral Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy in Medication-Resistant Essential Tremor Treatment.
Objective: To assess the efficacy and safety of bilateral magnetic resonance imaging-guided focused ultrasound thalamothomy for medication refractory essential tremor in prospective observation of two…Classical Machine Learning approaches to automate tremor detection from electrophysiological data
Objective: To detect tremor syndromes from electrophysiological signatures using classical machine learning techniques. Background: Electromyographic recordings combined with accelerometry data are widely used to measure…Diffusion-weighted imaging based free-water investigation in Parkinsonian disorders
Objective: To investigate free-water (FW) changes in Parkinson's disease (PD), Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Background: Various parkinsonian syndrome includes PD,…Unilateral Hypertrophic Olivary Degeneration in Anti-GAD-associated Encephalomyelitis
Objective: We present a patient with GAD65-Ab-related encephalomyelitis who developed unilateral hypertrophic olivary degeneration (HOD) in the absence of structural lesions within the Guillain-Mollaret triangle.…Computer vision can detect changes in bradykinesia associated with dopaminergic state in Parkinson’s disease
Objective: To evaluate the classification accuracy of a computer vision-based feature extraction and classifier method to detect changes in finger tap bradykinesia associated with dopaminergic…Efficacy of Apomorphine Sublingual Film Versus Subcutaneous Apomorphine for the Treatment of OFF Episodes in Parkinson’s Disease
Objective: Evaluate efficacy and patient satisfaction associated with apomorphine sublingual film (SL-APO) vs subcutaneous apomorphine (SC-APO) for the treatment of OFF episodes in patients with…Longitudinal Assessessment of Social Cognition in de novo PD patients and its Relationship with Striatal Dopaminergic Innervation
Objective: To prospectively assess social cognition (SC) in newly diagnosed, cognitively normal Parkinson’s disease (PD) patients and its relationship with striatal dopaminergic innervation. Background: SC…
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